Microbial Cell, 2020 RAD52 is a structurally and functionally conserved component of the DNA double-strand break (DSB) repair apparatus from budding yeast to humans. We recently showed that expressing the human gene, HsRAD52 in rad52 mutant budding yeast cells can suppress ...
Alissa D. Clear +13 more
doaj +1 more source
A quantitative study of the Hog1 MAPK response to fluctuating osmotic stress in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2010 Yeast cells live in a highly fluctuating environment with respect to temperature, nutrients, and especially osmolarity. The Hog1 mitogen-activated protein kinase (MAPK) pathway is crucial for the adaption of yeast cells to external osmotic changes.To ...
Zhike Zi +2 more
doaj +1 more source
Regulation of processing body formation in the budding yeast "Saccharomyces cerevisiae" [PDF]
, 2014 The life cycle of mRNA, from transcription to decay, is a tightly regulated biological process. mRNA is an essential molecule that the cell utilizes to alter gene expression. Degradation is one process through which the cell can regulate mRNA levels.
Weidner, Julie
core +1 more source
Spindle checkpoint activation by fungal orthologs of the S. cerevisiae Mps1 kinase.
PLoS ONEThere is an ongoing need for antifungal agents to treat humans. Identification of new antifungal agents can be based on screening compounds using whole cell assays.
Amy Fabritius +4 more
doaj +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Budding Yeast Strainsand Genotype-Phenotype mapping
, 2015 A small number of well-studied laboratory strains of Saccharomyces cerevisiae, mostly derived from S288C, are used in yeast research. Although powerful, studies for understanding S288C do not always capture the phenotypic essence or the genetic ...
Blomberg, Anders, +2 more
core +1 more source
Regulation of Mec1 (ATR) signaling in budding yeast [PDF]
, 2014 Cells are continuously challenged by various sources of DNA damage that can contribute to cancer formation if not appropriately repaired. To cope with this threat, cells have conserved mechanisms called the DNA damage checkpoints that sense damaged DNA ...
Hustedt, Nicole
core +1 more source
Role of the structural organisation of pericentromeres in chromosome segregation in budding yeast [PDF]
, 2020 Genome maintenance, function and transmission requires the adequate structural organisation of chromosomes. Central to this is the conserved ring-shaped protein complex, cohesin, that associates with chromosomes.
Paldi, Flora
core +1 more source
Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant
G3: Genes, Genomes, Genetics, 2017 Drug resistance is a consequence of how most modern medicines work. Drugs exert pressure on cells that causes death or the evolution of resistance. Indeed, highly specific drugs are rendered ineffective by a single DNA mutation.
Lai H. Wong +5 more
doaj +1 more source
Sgo1 regulates both condensin and Ipl1/Aurora B to promote chromosome biorientation. [PDF]
PLoS Genetics, 2014 Correct chromosome segregation is essential in order to prevent aneuploidy. To segregate sister chromatids equally to daughter cells, the sisters must attach to microtubules emanating from opposite spindle poles.
Karolina Peplowska +2 more
doaj +1 more source