Investigation of FEAR and MEN pathway homologs in multinucleate cells [PDF]
The cell cycle is a sequence of events enabling a cell to replicate and proliferate. Common landmark events in most eukaryotic cell cycles are duplication of the DNA, mitosis, and cell separation.
Finlayson, Mark
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The integrated stress response in budding yeast lifespan extension [PDF]
Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion.
Jessica K. Tyler +2 more
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Regulation of sporulation in the yeast Saccharomyces cerevisiae. [PDF]
Sporulation of the budding yeast Saccharomyces cerevisiae — equivalent to gametogenesis in higher organisms, is a complex differentiation program induced by starvation of cells for nitrogen and carbon.
Rytka, Joanna +5 more
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The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback [PDF]
The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply
Brazma Alvis +30 more
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In many eukaryotes, the centromere is epigenetically specified and not strictly defined by sequence. In contrast, budding yeast has a specific 125 bp sequence required for kinetochore function.
Kung-Hsien Ho +3 more
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Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint [PDF]
Mitotic progression is controlled by proteolytic destruction of securin and cyclin. The mitotic E3 ubiquitin ligase, known as the anaphase promoting complex or cyclosome (APC/C), in partnership with its activators Cdc20p and Cdh1p, targets these proteins
Emma M J King +8 more
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Analysis of the transcriptional program governing meiosis and gametogenesis in yeast and mammals [PDF]
During meiosis a competent diploid cell replicates its DNA once and then undergoes two consecutive divisions followed by haploid gamete differentiation.
Schlecht, Ulrich
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TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation
Summary: In response to environmental cues, such as nutrient starvation, living organisms modulate gene expression through mechanisms involving histone modifications.
Hayato Hirai +3 more
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urg1: A Uracil-Regulatable Promoter System for Fission Yeast with Short Induction and Repression Times [PDF]
Background. The fission yeast Schizosaccharomyces pombe is a popular genetic model organism with powerful experimental tools. The thiamine-regulatable nmt1 promoter and derivatives, which take > 15 hours for full induction, are most commonly used for ...
Mata, J +23 more
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Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
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