Results 111 to 120 of about 18,176,359 (256)
, 1889 This is the eleventh volume in the College of Wooster\u27s Index collection. The 1889 Index was published by editors elected from the Junior Class as representatives of the university\u27s fraternities.
Index Editors,
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
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THE BUFFER ROLE OF GROUNDWATER WHEN SURFACE WATER SUPPLIES ARE UNCERTAIN: THE IMPLICATIONS FOR GROUNDWATER DEVELOPMENT [PDF]
When used in conjunction with surface water for irrigation, groundwater serves two roles: to increase water supply; and to mitigate fluctuations in the supply of water. The later is the buffer role.
Tsur, Yacov
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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Ecological IndicatorsUrban river water pollution is a serious environmental challenge confronting urban areas worldwide. The scientific quantification of the impact of landscape patterns on water quality provides essential support for pollution control and watershed ...
Kun Mei +6 more
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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LandNational parks are widely recognized as a key spatial conservation strategy for simultaneously safeguarding biodiversity and sustaining ecosystem services, yet comprehensive and causally robust evaluation frameworks are still needed to accurately assess ...
Chuqi Wang +3 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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