Results 91 to 100 of about 18,176,359 (256)

The Central European buffer zone [PDF]

This paper considers the creation of a new region in Europe since the opening of the borders following the so-called "revolutions" in East-Central Europe.
Claire Wallace
core  

Ticks in the landscape: Fragmentation impacts density of Europe’s principal tick-borne disease vector, Ixodes ricinus, across Germany

Ticks and Tick-Borne Diseases
Tick-borne diseases (TBDs) constitute a considerable challenge for human and animal health. Understanding the driving forces of TBD risk is key to developing effective prevention strategies, particularly in light of human-nature interfaces or increasing ...
Andrea Springer, Olaf Kahl, Nina Król, Martin Pfeffer, Lidia Chitimia-Dobler, Alexander Lindau, Ute Mackenstedt, Christina Strube   +7 more
doaj   +1 more source

Defining and Systematic Analyses of Aggregation Indices to Evaluate Degree of Calcium Oxalate Crystal Aggregation

Frontiers in Chemistry, 2017
Crystal aggregation is one of the most crucial steps in kidney stone pathogenesis. However, previous studies of crystal aggregation were rarely done and quantitative analysis of aggregation degree was handicapped by a lack of the standard measurement. We
Sakdithep Chaiyarit, Visith Thongboonkerd   +1 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Link-level travel time measures-based level of service thresholds by the posted speed limit

Transportation Research Interdisciplinary Perspectives, 2019
Macroscopic parameters, such as density, volume-to-capacity ratio, and speed, are traditionally used to assess the level of service (LOS) of freeway/expressway or arterial road links.
Swapneel R. Kodupuganti, Srinivas S. Pulugurtha   +1 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The Buffer-Stock Theory of Saving: Some Macroeconomic Evidence [PDF]

macroeconomics, Buffer-Stock Theory of Saving ...
Christopher D. Carroll
core  

Estimating uncertainty and Misery (Index) of the paratransit experience

Transportation Research Interdisciplinary Perspectives
Transportation access significantly impacts inclusion, well-being, and health. However, people with disabilities often struggle to use fixed-route transit due to mobility challenges.
Aditi Misra, Wesley Marshall, Lucy O’Sullivan, Molly Wagner, Manish Shirgaokar   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source