Results 81 to 90 of about 18,176,359 (256)

Feel the Time. Time Perception as a Function of Interoceptive Processing

Frontiers in Human Neuroscience, 2018
The nature of time is rooted in our body. Constellations of impulses arising from the flesh constantly create our interoceptive perception and, in turn, the unfolding of these perceptions defines human awareness of time.
Daniele Di Lernia, Silvia Serino, Silvia Serino, Giovanni Pezzulo, Elisa Pedroli, Pietro Cipresso, Pietro Cipresso, Giuseppe Riva, Giuseppe Riva   +8 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Subject Index and Author Index

Subject Index and Author ...
-, - INDEX
core   +4 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Supply of an ecosystem service—Farmers’ willingness to adopt riparian buffer zones in agricultural catchments [PDF]

, 2012
peer-reviewedTeagasc Agricultural Catchments Programme Phase 1 (2008-2011) and Phase 2 (2012-2015)In the European Union, mitigation measures to abate diffuse pollution from agricultural land are implemented under the direction of the EU Nitrates and ...
Buckley, Cathal, Hynes, Stephen, Mechan, Sarah   +2 more
core   +1 more source

Index 1918 [PDF]

, 1918
This is volume 37 of the College of Wooster’s Index collection. The Index is the college’s yearbook, it includes an annual record of events at Wooster. This edition was published by the class of 1918.
Index Editors,
core   +1 more source

GLMI: An Efficient Spatiotemporal Index Leveraging Geohash and Piecewise Linear Models for Optimized Query Performance

Algorithms
Spatiotemporal big data contain information in multiple dimensions such as space and time. Spatiotemporal data have the characteristics of large volume, intricate spatiotemporal relationship, and uneven spatiotemporal distribution. Index structure is one
Kun Chen, Gang Liu, Genshen Chen, Zhengping Weng, Qiyu Chen   +4 more
doaj   +1 more source

Associations of the perceived and objective neighborhood environment with physical activity and sedentary time in New Zealand adolescents

International Journal of Behavioral Nutrition and Physical Activity, 2017
Background There is accumulating evidence supporting the association between neighborhood built environments and adults’ physical activity (PA) and sedentary time (ST); however, few studies have investigated these associations in adolescents.
Erica Hinckson, Ester Cerin, Suzanne Mavoa, Melody Smith, Hannah Badland, Tom Stewart, Scott Duncan, Grant Schofield   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source