Results 161 to 170 of about 251,253 (308)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Are Bank Capital Buffers Cyclical? Evidence from Developed and Developing Countries

, 2013
[[abstract]]This study examines the relationship between the capital buffers (including common equity buffers) and business cycle fluctuations. Furthermore, this study investigates whether the behavior of bank capital and common equity buffers is ...
Chen, Yi-Kai;Ho, Amy Yueh-Fang;Hsu, Ching-Lan
core  

Solution Phase Protein Dynamics: Influences of ESI Buffers on Hydration. [PDF]

Anal Chem
Burningham E, Lantz C, Rider RL, Kuo ST, Yun SD, Laganowsky A, Russell DH.   +6 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

The Buffer Illusion: How TRIS and HEPES Enhance Bioactivity of Bioglass 45S5. [PDF]

ACS Omega
Přívracká T, Opavová K, Bezdička P, Labuta J, Rohanová D.   +4 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Protocol for mechanical nuclei dissociation and isolation from frozen tissue and organoids for single-nucleus RNA sequencing. [PDF]

STAR Protoc
Guillon M, Brin M, Laurent L, Flamier A.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Calibration of a solid-state copper ion-selective electrode in cupric ion buffers containing chloride

, 1991
It is shown that near-Nernstian calibration slopes can be obtained with a Cu1.8Se electrode in a range of cupric ion buffers in spite of a high chloride content. Best results are obtained with the ligands ethylenediamine, glycine and histidine. The onset
Boy Hoyer
core  

Identifying the proton donor in electrocatalytic hydrogen evolution by a model hydrogenase. [PDF]

J Biol Inorg Chem
Stein RE, Wertz AE, Moore PJ, Shafaat HS.   +3 more
europepmc   +1 more source