Results 181 to 190 of about 191,924 (266)

Identification of cellular ion channels that facilitate Hazara nairovirus infection enables selection of clinically approved compounds with anti-nairoviral properties. [PDF]

Sci Rep
Charlton FW, Hover SE, Alyahyawi A, Pearson HM, Edwards TA, Mankouri J, Stacey M, Fontana J, Barr JN.   +8 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Nuclear Spin-Free ⁷⁰Ge/²⁸Si⁷⁰Ge Quantum Well Heterostructures Grown on Industrial SiGe-Buffered Wafers. [PDF]

Adv Sci (Weinh)
Daoust P, Rotaru N, Biswas D, Koelling S, Rahier E, Dubé-Valade A, Vecchio PD, Edwards MS, Tanvir M, Sajadi E, Salfi J, Moutanabbir O.   +11 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

An Improved Beta Burst Extraction for Chip-Based Deep Brain Stimulation With Real-Time Model Updating. [PDF]

IEEE Open J Eng Med Biol
Ou-Yang YH, Lin HC, Huang CW, Wu CY, Ker MD, Lee CY.   +5 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Investigation on a Freeze-Drying Process for Long-Term Stability of mRNA-LNPs. [PDF]

Vaccines (Basel)
Khan MDFH, Sudalaiyadum Perumal A, Kamen AA.   +2 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Bat Ripple case study shows ecological and economic contributions of grey headed flying foxes in Australia. [PDF]

Sci Rep
Ortega González A, Possingham H, Biggs D, Anderson N, Braczkowski AR.   +4 more
europepmc   +1 more source