Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Rediscovery Datasets: Connecting Duplicate Reports
The same defect can be rediscovered by multiple clients, causing unplanned outages and leading to reduced customer satisfaction. In the case of popular open source software, high volume of defects is reported on a regular basis.
Bener, Ayse Basar +2 more
core +1 more source
Functional Connectivity Linked to Cognitive Recovery After Minor Stroke
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri +7 more
wiley +1 more source
You Cannot Fix What You Cannot Find! An Investigation of Fault Localization Bias in Benchmarking Automated Program Repair Systems [PDF]
Properly benchmarking Automated Program Repair (APR) systems should contribute to the development and adoption of the research outputs by practitioners.
Bissyandé, Tegawendé F. +5 more
core +2 more sources
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Usability discussions in open source development [PDF]
The public nature of discussion in open source projects provides a valuable resource for understanding the mechanisms of open source software development. In this paper we explore how open source projects address issues of usability.
Nichols, David M., Twidale, Michael B.
core +1 more source
Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim +3 more
wiley +1 more source
Nature-Based Prediction Model of Bug Reports Based on Ensemble Machine Learning Model
In software development systems, the maintenance process of software systems attracted the attention of researchers due to its importance in fixing the defects discovered in the software testing by using bug reports (BRs) which include detailed ...
Shatha Abed Alsaedi +3 more
doaj +1 more source
Effective Bug Triage based on Historical Bug-Fix Information [PDF]
International audienceFor complex and popular software, project teams could receive a large number of bug reports. It is often tedious and costly to manually assign these bug reports to developers who have the expertise to fix the bugs.
Hu, Hao +3 more
core +2 more sources
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu +5 more
wiley +1 more source

