Results 71 to 80 of about 129,057 (230)

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Deep Learning With Customized Abstract Syntax Tree for Bug Localization

IEEE Access, 2019
Given a bug report, bug localization technique can help developers automatically locate potential buggy files. Information retrieval and deep learning approaches have been applied in bug localization by extracting lexical features in bug reports and ...
Hongliang Liang, Lu Sun, Meilin Wang, Yuxing Yang   +3 more
doaj   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Knowledge Bases and Representation Learning Towards Bug Triaging

Machine Learning and Knowledge Extraction
A large number of bug reports are submitted by users and developers in bug-tracking system every day. It is time-consuming for software maintainers to assign bug reports to appropriate developers for fixing manually.
Qi Wang, Weihao Yan, Yanlong Li, Yizheng Ge, Yiwei Liu, Peng Yin, Shuai Tan   +6 more
doaj   +1 more source

Enhancing bug allocation in software development: a multi-criteria approach using fuzzy logic and evolutionary algorithms [PDF]

PeerJ Computer Science
A bug tracking system (BTS) is a comprehensive data source for data-driven decision-making. Its various bug attributes can identify a BTS with ease.
Chetna Gupta, Varun Gupta
doaj   +2 more sources

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Big-data based intelligent bug triage techniques for open-source projects

大数据, 2021
Bug triage aims to determine the priority and repair measures and is critical in ensuring software trustability. However, in the increasingly popular open-source projects, due to a large number of defects and lack of organization and management, it is ...
Shengqu XI, Feng XU, Xin CHEN, Xuandong LI   +3 more
doaj  

We Don't Need Another Hero? The Impact of "Heroes" on Software Development

, 2018
A software project has "Hero Developers" when 80% of contributions are delivered by 20% of the developers. Are such heroes a good idea? Are too many heroes bad for software quality?
Bier Norman, Cabot Jordi, Cullom Charmayne, Ghotra Baljinder, Goeminne Mathieu, Kocaguneli E., Morcov Stefan, Pinto Gustavo   +7 more
core   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

An Attribute Selection For Severity Level Determination According To The Support Vector Machine Classification Result

, 2012
Determination of bug severity level is needed in fixing bug. Actually, in bug-tracking system, there is around 14 attributes used for defining a bug. But, all this time we do not know which attributes are highly influential for this. In this research, a
Ghaluh Indah Permata , Sari
core