Results 71 to 80 of about 9,237,687 (277)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
"Building" exact confidence nets [PDF]
, 2016 Confidence nets, that is, collections of confidence intervals that fill out the parameter space and whose exact parameter coverage can be computed, are familiar in nonparametric statistics.
Francis, Andrew R. +2 more
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Energy Science & Engineering, 2020 In order to attain an efficient path into the enhancement of the sustainable conservation and management of energy resources in the buildings and residential sections, efforts by all relevant institutions in the area of energy are essential and primitive.
Saeed Esbati +5 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Mokslas: Lietuvos Ateitis, 2016 Lithuania is currently intensively starting to develop BIM technology. BIM is the process by which information regarding construction is generated and managed. There is considerable information affecting each building (its planning, design, construction,
Aurelija Peckienė
doaj +1 more source
AJN, American Journal of Nursing, 2021 Nurses can help change the course of the COVID-19 pandemic.
openaire +3 more sources
Evaluative Language and Its Solidarity-Building Role on TED.com: An Appraisal and Corpus Analysis [PDF]
, 2015 Language is a key resource in the formation of online communities, which are in turn central to an understanding of contemporary social relations. This study looks at TED.com, an educational video-hosting platform with few in-built community-building ...
Drasovean, Anda, Tagg, Caroline
core