Results 61 to 70 of about 709,095 (293)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Optimizing the performance of concrete tiles using nano-papyrus and carbon fibers

Open Engineering
Concrete is considered one of the greatest innovations in the construction industry since it has significant applications in the construction field. The main limitation of concrete is the low flexural and tensile strength, especially for concrete tiles ...
Jawad Zahraa Fakhri, Salim Lamyaa Ghanim, Hussain Sarah Silan, Salman Awham J., Radhi Sabaa   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Building a Sustainable Construction Workforce [PDF]

International Journal of Environmental Research and Public Health, 2019
The average U.S. construction worker is aged 42.6 years, and will not be eligible for full Social Security retirement benefits until age 67. Delayed retirement is largely driven by economic need, but construction workers face considerable challenges in remaining on the job. This study explores trade-specific age trends within the construction industry,
Sokas, Rosemary K., Dong, Xiuwen Sue, Cain, Chris Trahan   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effect of different buried depth on the disintegration characteristic of red-bed soft rock and the evolution model of disintegration breakage under cyclic drying-wetting

Scientific Reports
The disintegration of red-bed soft rock exhibits a strong correlation with various geological disasters. However, the investigation into the evolutionary mechanisms underlying disintegration breakage has not yet received extensive exploration.
Jun Zhang, Yang Guo, Kai Huang, Wei Cui, Zhaibang Ke, Xiaochuang Chen, Tengsheng Yue, Kun Gao   +7 more
doaj   +1 more source

CFD simulation of the convective flows in the vertical caverns [PDF]

Инженерно-строительный журнал, 2019
The purpose of this paper is determination the critical geometric dimensions of a three-dimensional vertical heated cavern. In this rate the convection's contribution to heat transfer will be limited due to thermal conductivity at a fixture temperature ...
M.R. Petrichenko, V.V. Sergeev, D. Nemova, E.V. Kotov, D.S. Andreeva   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Construction: use waste for building [PDF]

Nature, 2017
As construction work in India soars and the pressure on stone and other natural resources mounts, the Bureau of Indian Standards has called for good-quality building materials to be made from waste products. A proof of concept for this waste valorization has been developed by the Indo-UK Centre for Environment Research and Innovation (IU-CERI; see www ...
Tripathi, Nimisha, Hills, Colin D., Singh, Raj S., Carey, Paula J.   +3 more
openaire   +2 more sources

Building procurement methods [PDF]

, 2004
A plethora of methods for procuring building projects are available to meet the needs of clients. Deciding what method to use for a given project is a difficult and challenging task as a client’s objectives and priorities need to marry with the selected ...

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