Results 31 to 40 of about 39,445 (266)

A Smart Building Resource Prediction, Navigation and Management System Supported by Radio Tomography and Computational Intelligence

Energies, 2021
This article presents research results on a smart building prediction, navigation and asset management system. The main goal of this work was to combine all comfort subsystems, such as lighting, heating or air conditioning control, into one coherent ...
Michał Styła, Przemysław Adamkiewicz, Tomasz Cieplak, Stanisław Skowron, Artur Dmowski, Józef Stokłosa   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Low-Cost Extra-Low Voltage LED Dimmer for Tuneable White Lighting

Elektronika ir Elektrotechnika, 2019
The colour appearance of light sources has a major impact on how people perceive space. With LED illumination lighting, the colour output can be tuned to virtually any perceivable colour, including any hue of white light. It has been established that the
Roman Hrbac, Tomas Mlcak, Vaclav Kolar, Tomas Vantuch   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Assessment of the challenges influencing the adoption of smart building technologies

Frontiers in Built Environment
Introduction: Over the past few decades, there has been an increasing focus on Smart Building Projects (SBP) and the technologies associated with them.
Saleh Baharetha, Ashraf M. Soliman, Ashraf M. Soliman, Mohammad A. Hassanain, Mohammad A. Hassanain, Adel Alshibani, Adel Alshibani, Mohamed Salah Ezz, Mohamed Salah Ezz   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Modeling and Simulation Tools for Smart Local Energy Systems: A Review with a Focus on Emerging Closed Ecological Systems’ Application

Applied Sciences
The growing importance of microgrids—linking buildings with distributed energy resources and storage—is driving the evolution of Smart Local Energy Systems (SLESs).
Andrzej Ożadowicz
doaj   +1 more source

Challenges in Getting Building Performance Monitoring Tools for Everyday Use: User Experiences with A New Tool

Buildings, 2014
There is a need for building performance monitoring because it is common that buildings do not perform as intended. A number of advanced tools for the purpose have been developed within the last tens of years.
Heikki Ihasalo, Sami Karjalainen
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source