Results 21 to 30 of about 3,039,727 (240)

The Series – Serial work in artistic research and in the didactics of the arts

open access: yesInFormation: Nordic Journal of Art and Research, 2013
The series is a paradoxical phenomenon in artistic work. The term “series” signifies copying, repetition, reproduction and frequently even trivialization – to break with the idea of the original. However, serial work is simultaneously central both in the
Aslaug Nyrnes
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

The Arabian patrimonial industries and crafts,and their role in building the Islamic personality

open access: yesJournal of Architecture, Art & Humanistic Science, 2016
This research has dealt with some Arab inherited industries and crafts that were implemented in the manner of relief sculpture and the impact of the environment and nature on the Muslim artist, and the role played by the nature and environment in the ...
Salwa El Tahir
doaj   +1 more source

Situated Computations: Bridging Craft and Computation in the Trinidad and Tobago Carnival

open access: yesDearq, 2020
Hand crafts, and the people who practice them, are typically seen as opposite to digital technologies. This paper challenges this split, and proposes eight principles for developing computational design tools that facilitate productive interactions ...
Noel Vernelle
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Blogging, craft culture, and women empowerment

open access: yesCogent Social Sciences, 2017
The study presents an analysis of the development process that women crafters underwent who began blogging as a hobby and gradually turned their crafts into blog-supported small businesses.
Idit Manosevitch, Yonit Tzuk
doaj   +1 more source

Theory building is neither an art nor a science. It is a craft [PDF]

open access: yesJournal of Information Technology, 2020
Researchers often hold a romantic view of theory, which they feel should be a complete, flawless, deep, and exhaustive explanation of a phenomenon. They also often hold a romantic view of theory building, which they envision either as emerging from trancelike writing or as the product of a straightforward deductive process.
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

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