Results 21 to 30 of about 5,299 (256)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Theory building is neither an art nor a science. It is a craft [PDF]

Journal of Information Technology, 2020
Researchers often hold a romantic view of theory, which they feel should be a complete, flawless, deep, and exhaustive explanation of a phenomenon. They also often hold a romantic view of theory building, which they envision either as emerging from trancelike writing or as the product of a straightforward deductive process.
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Arabian patrimonial industries and crafts,and their role in building the Islamic personality

Journal of Architecture, Art & Humanistic Science, 2016
This research has dealt with some Arab inherited industries and crafts that were implemented in the manner of relief sculpture and the impact of the environment and nature on the Muslim artist, and the role played by the nature and environment in the ...
Salwa El Tahir
doaj   +1 more source

Situated Computations: Bridging Craft and Computation in the Trinidad and Tobago Carnival

Dearq, 2020
Hand crafts, and the people who practice them, are typically seen as opposite to digital technologies. This paper challenges this split, and proposes eight principles for developing computational design tools that facilitate productive interactions ...
Noel Vernelle
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Blogging, craft culture, and women empowerment

Cogent Social Sciences, 2017
The study presents an analysis of the development process that women crafters underwent who began blogging as a hobby and gradually turned their crafts into blog-supported small businesses.
Idit Manosevitch, Yonit Tzuk
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Landhuis De Hoeve (1913) van Robert van ’t Hoff. Het Hollandse landhuis en de Moderne Beweging

Bulletin KNOB, 2016
This article seeks to determine the significance of the De Hoeve country house in the oeuvre of Robert van ’t Hoff (1887–1979), and in what way the design contributes to the development of a vernacular building style in the early history of the Modern ...
Dolf Broekhuizen
doaj   +1 more source