Results 141 to 150 of about 1,522,294 (308)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Stacking of DT, RF, and Gradient Boosting Algorithms for Classification of Building Damage Due to Earthquakes

Journal of Applied Informatics and Computing
Classification of building damage levels due to earthquakes is an important aspect in disaster mitigation and post-disaster risk assessment. This study aims to improve classification accuracy on imbalanced data using an ensemble stacking method.
Nur Aqliah Ilmi, Nurul Anisa Sri Winarsih   +1 more
doaj   +1 more source

Classification of Heavily Damaged Building Damage after Earthquake

Doğal Afetler ve Çevre Dergisi, 2016
In this study, severe damage types in concrete buildings observed after earthquakes were classified and investigated in relation to the structural behaviors. Since the damage types are very extensive, particularly heavy damages caused by column and combination of beam-column damages were discussed. Classification is made primarily in the form of damage
openaire   +1 more source

Beyond sustainable buildings: eco-efficiency to eco-effectiveness through cradle-to-cradle design [PDF]

, 2013
Sustainable building development focuses on achieving buildings that meet performance and functionality requirements with minimum adverse impact on the environment.
Ankrah, NA, Awuah, KGB, Hammond, FN, Manu, E, Tannahill, K   +4 more
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Improving Loss Estimation for Woodframe Buildings. Volume 2: Appendices [PDF]

, 2002
This report documents Tasks 4.1 and 4.5 of the CUREE-Caltech Woodframe Project. It presents a theoretical and empirical methodology for creating probabilistic relationships between seismic shaking severity and physical damage and loss for buildings in ...
Beck, James L., Boyd, Tom, Porter, Keith A., Scawthorn, Charles R., Seligson, Hope A., Tobin, L. Thomas, Young, Ray   +6 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Seismic vulnerability assessment of the old city centre of Seixal, Portugal [PDF]

, 2012
The seismic vulnerability assessment of old traditional masonry building stocks, in a seismic risk mitigation perspective, is truly essential not only for buildings with recognized historical and patrimonial value, but also, in relation to regular ...
Costa, A., Ferreira, T., Mendes da Silva, J. A. R., Varum, H., Vicente, R.   +4 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Design methodology for a community response questionnaire on sonic boom exposure [PDF]

A preliminary draft questionnaire concerning community response to sonic booms was developed. Interviews were conducted in two communities that had experienced supersonic overflights of the SR-71 airplane for several years.
Demiranda, Gwendolyn A., Farbry, John E., Jr., Fields, James M., Molino, John A.   +3 more
core   +1 more source