Results 81 to 90 of about 1,522,294 (308)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Development of building vulnerability functions in subsidence regions from analytical methods [PDF]

, 2012
Ore and mineral extraction by underground mining often causes ground subsidence phenomena, and may induce severe damage to buildings. This paper develops vulnerability and fragility functions to assess building damage in the context of mining subsidence ...
Deck, Olivier, Saeidi, Ali, Verdel, Thierry   +2 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Seismic vulnerability of churches in Faial and Pico islands, Azores [PDF]

, 2012
Earthquakes represent one of the main cause of serious damage and loss of historic and architectural heritage. Interventions to preserve these building should start with a careful knowledge and assessment of their seismic vulnerability, in order to ...
Costa, A., Curti, E., Ferreira, T., Lagomarsino, S., Magalhães, J. M., Varum, H., Vicente, R.   +6 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Building damage in Westport

Bulletin of the New Zealand Society for Earthquake Engineering, 1969
The earthquake of 24 May 1968, was the second of damaging intensity to be experienced in Westport recently. The earlier (1962) quake was of smaller magnitude; but centred, as it was, at Westport it was probably felt with comparable intensity there.
openaire   +2 more sources

Hygrothermal performance of building envelopes in the tropics under operative conditions : condensation and mould growth risk appraisal [PDF]

, 2016
Poor indoor hygrothermal performance increases the risk of indoor moisture problems and deterioration due to mould growth, corrosion and damage to archival materials. Hence, proper control of indoor thermohygric intensity abates indoor moisture and its
Ali, M, Ibrahim, MS, Mohd Din, SA, Oladokun, MO, Osman, SB, Yusof, F   +5 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Evaluation of Damage to Existing Buildings Induced by Tunnel Excavation

Infrastructures
This study emphasizes the significance of employing systematic approaches and precise modeling techniques to evaluate potential building damage from metro tunnel excavations. Mair et al.
Ekin Evrim Laçin Akşit, Kadir Güler
doaj   +1 more source

Geographic analysis of earthquake damage in Turkey between 1900 and 2012

Geomatics, Natural Hazards & Risk, 2016
This study investigates the relationship between fatality and magnitude, energy released, time of earthquake occurrence and building damage, and between building damage and magnitude and energy of earthquakes that occurred in Turkey between 1900 and 2012.
Kemal Gökkaya
doaj   +1 more source