Results 171 to 180 of about 132,806 (311)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Adopting a user-centred design approach for the development of on-device technology to prevent the viewing of child sexual abuse material: app design insights and principles from the development of 'Salus'. [PDF]

open access: yesFront Psychiatry
Davy D   +13 more
europepmc   +1 more source

The Multifunctional Attributes of Northeastern Agriculture: A Research Agenda

open access: yes
In the United States' Northeastern region, there is an increasing interest in the public benefits from agriculture. These benefits are frequently referred to as multifunctional attributes. The policy challenge is to find an effective way to reflect these
Batie, Sandra S.
core  

Industrial property performance and building functionality

open access: yes, 2003
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Architecture, 2003.Includes bibliographical references (leaf 52).This paper uses statistical regression techniques, Ordinary Least Squares (OLS), to develop models to explain the relationship
Zhao, Yajie, 1970-
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Conservation of Functional Heritage Railway Buildings as an Archetype for the Conservation of Functional Heritage Buildings [PDF]

open access: yes
Conservation of heritage buildings has a theoretical basis dating from the Renaissance, popularised by the 18th Century ‘grand tour’ and codified by the 19th Century. This approach recognised great works of architecture and artistry, while consciously eschewing contemporary ‘functional’ buildings developed throughout the Industrial Revolution ...
openaire  

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