Results 91 to 100 of about 1,677,818 (304)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Building Facade Maintenance

Vestnik Tomskogo gosudarstvennogo arkhitekturno-stroitel'nogo universiteta. JOURNAL of Construction and Architecture
The article is devoted to the problem of providing access to building facades in order to maintain their operational characteristics.Purpose: The purpose of the study is to identify general principles of building facade maintenance that contribute to typification and unification of solutions, and develop practical recommendations for their application ...
L. D. Morshakova, G. A. Bardina, A. I. Zatsepina   +2 more
openaire   +1 more source

Buildings Lean Maintenance Implementation Model

Open Engineering, 2016
Abstract Nowadays, companies in global markets have to achieve high levels of performance and competitiveness to stay “alive”.Within this assumption, the building maintenance cannot be done in a casual and improvised way due to the costs related.
Abreu, António, Calado, João Manuel Ferreira, Requeijo, José   +2 more
openaire   +3 more sources

Studi Penentuan Indeks Kondisi Bangunan dan Biaya Renovasi Bangunan Lama Fakultas Kehutanan Universitas Tanjungpura Pontianak [PDF]

, 2016
Budget Plan costs and maintenance activities, as well as in the implementation of maintenance management activities are expected to maintain the physical condition of the building and reduce the chances of a building that is not functioning optimally ...
Pratiwi, R. (Riyanny), Syahrudin, S. (Syahrudin), Watty, S. M. (Susan)   +2 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Performance Assessment of Maintenance Practices in Government Office Buildings: Case Study of Parcel E, Putrajaya

MATEC Web of Conferences, 2014
Building maintenance practices must be taken into consideration by building facility managers or building owners. They involve daily operations to ensure that end users can work or live comfortably and safely. Through effective maintenance practices, the
Awg Husaini A.I., Tabassi A.A.
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Endurance of the wooden bridge reinforced by the dowel plates

Studia Geotechnica et Mechanica, 2018
The most important piece of road infrastructure is bridges. Wooden bridges have advanced constantly during the past decades. The trend began in Scandinavian countries but has also now gained significant ground in Russia.
Dahoua Lamri, Boymatov Fakhridine
doaj   +1 more source

COLLABORATIVE SYSTEMS AND MATHEMATICAL MODELS FOR LEADING ECONOMIC PROCESSES [PDF]

A collaborative system is an interdisciplinary field located at the intersection of economics, computer science, management and sociology. These systems are focused on building connections between people, equipment and information.
Irina Barbu
core