Results 131 to 140 of about 261,938 (308)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Maintenance Building: Behind treeline
, 2020 The black and white photographs document the early development of the ...
Commonwealth News and Information Bureau +1 more
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A Cross-Domain Decision Support System to Optimize Building Maintenance
, 2019 Operations and maintenance optimization are primary issues in Facility Management (FM). Moreover, the increased complexity of the digitized assets leads Facility Managers to the adoption of interdisciplinary metrics that are able to measure the peculiar ...
Fulvio Re Cecconi, Nicola Moretti
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Maintenance Building: Worskshops
, 2020 The black and white photographs document the early development of the ...
Commonwealth News and Information Bureau +1 more
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Building Maintenance & Construction: Tools and Maintenance Tasks
, 2021 Building Maintenance & Construction: Tools and Maintenance Tasks introduces and develops knowledge of basic building maintenance tools and materials/ applied skills and techniques/ industry health and safety standards/ and preventive maintenance and ...
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Maintenance Building: Main entrance
, 2020 The black and white photographs document the early development of the ...
Commonwealth News and Information Bureau +1 more
core
Building Maintenance Management [PDF]
Journal of Building Appraisal, 2007 Barrie Chanter, Peter Swallow
openaire +3 more sources