Results 131 to 140 of about 1,677,818 (304)

Building Maintenance Management

, 2021
Buildings are some of the most valuable assets of any nation, in the sense that they provide people shelter, places to work and leisure, and so many others functions. With the rising costs of new buildings, the need for Building Maintenance (BM), has become even more relevant, since it allows the qualification of the built portfolio, helps boosting the
openaire   +1 more source

Monitoring of air ducting using mechanical robot for indoor air quality (IAQ) improvement [PDF]

, 2013
Indoor Air Quality (IAQ) has become public concern recently. Air ducting is used in Mechanical Ventilation and Air Conditioning (MVAC) system to deliver air to the building occupants. Without proper maintenance of the ducting system, it will affect
Muhamad Damanhuri, Amir Abdullah
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Influence of Mixing Conditions on the Strength and Microstructure of Cement Paste

Buildings
The conventional “one-pot” mixing method employed in concrete production restricts both efficiency and quality optimization. This study systematically investigates the effects of mixing duration and rotational speed on the compressive strength and ...
Yufan Wan, Hongbo Cao, Guangqiao Zhang, Xue Lu, Yanru Gao, Jintao Niu, Chuang He, Xiaolei Lu   +7 more
doaj   +1 more source

Working Notes from the 1992 AAAI Workshop on Automating Software Design. Theme: Domain Specific Software Design [PDF]

The goal of this workshop is to identify different architectural approaches to building domain-specific software design systems and to explore issues unique to domain-specific (vs. general-purpose) software design. Some general issues that cut across the
Barstow, David, Keller, Richard M., Lowry, Michael R., Tong, Christopher H.   +3 more
core   +1 more source

Aerial robotics in building inspection and maintenance [PDF]

, 2018
Buildings need periodic revision about their state, materials degrade with time and repairs or renewals have to be made driven by maintenance needs or safety requirements.
Bolea Monte, Yolanda, Grau Saldes, Antoni, Guerra Paradas, Edmundo, Puig-Pey Clavería, Ana María, Sanfeliu Cortés, Alberto   +4 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Building Maintenance Management [PDF]

Journal of Building Appraisal, 2007
Barrie Chanter, Peter Swallow
openaire   +3 more sources