Results 121 to 130 of about 3,216,643 (295)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Durability and Cracking Defects in 3D-Printed Concrete
Advances in Civil EngineeringThis article explores the durability and cracking defects associated with 3D-printed concrete, a rapidly emerging technology in construction. As the demand for innovative building techniques grows, understanding the long-term performance of 3D-printed ...
Gintautas Skripkiunas +4 more
doaj +1 more source
Journal of MateriomicsDistortion manipulation emerges as an efficient approach to obtain desired perovskite phases for various applications. In part I of this study, we propose a paradigm to quantify the structural distortion manipulation, which enables us to obtain desired ...
Cheng Fang, Hong Wang, Siqi Shi
doaj +1 more source
The search for building-integrated PV materials with good aesthetic potential: a survey [PDF]
, 2011 Building-integrated photovoltaics (PV) is currently dominated by blue and black rectilinear forms. Greater variety of colour and form could lead to much better uptake of PV in the built environment, also increasing the potential for PV to be used ...
Hardy, DA +4 more
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
An unprecedented 2D covalent organic framework with an htb net topology. [PDF]
, 2019 A 2D imine-linked COF with a hitherto unreported htb type topology was synthesized from a linear diamine linker and a judiciously designed tetra-aldehyde building block.
Cai, Song-Liang +7 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Anisotropy of machine building materials [PDF]
The results of experimental studies of the anisotropy of elastic and strength characteristics of various structural materials, including pressure worked metals and alloys, laminated fiberglass plastics, and laminated wood plastics, are correlated and ...
Ashkenazi, Y. K.
core +1 more source
Emission limit values for building materials. Environmental foundation and consequences for building materials [PDF]
, 2007 This report presents alternative emission limit values for inorganic components to be used in the revision of the Building Materials Decree (1999) in the Netherlands. Three key factors determine the emission limit value: (1) the environmental compartment
Broek HH van den +6 more
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