Results 71 to 80 of about 3,216,643 (295)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Validation and Discussion of a Comparative Method Based on Experiment to Determine the Effective Thickness of Composite Glass

Buildings
This study introduces and validates a comparative experiment-based method for determining the effective thickness of composite glass, including polymeric laminated glass (with polyvinyl butyral (PVB) and SentryGlas® (SGP) interlayers) and vacuum glazing.
Dake Cao, Xiaogen Liu, Zhe Yang, Jiawei Huang, Ming Xu, Detian Wan   +5 more
doaj   +1 more source

Microbial and metabolic succession on common building materials under high humidity conditions. [PDF]

, 2019
Despite considerable efforts to characterize the microbial ecology of the built environment, the metabolic mechanisms underpinning microbial colonization and successional dynamics remain unclear, particularly at high moisture conditions. Here, we applied
Cardona, Cesar, Gao, Peng, Gilbert, Jack A, Goodney, Gabriel, Gottel, Neil, Hartmann, Erica M, Henry, Chris, Kelley, Scott T, Lax, Simon, Stephens, Brent, Thomas, Paul M, Winton, Valerie J, Zhao, Dan   +12 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Electrochemistry and capillary condensation theory reveal the mechanism of corrosion in dense porous media

Scientific Reports, 2018
Corrosion in carbonated concrete is an example of corrosion in dense porous media of tremendous socio-economic and scientific relevance. The widespread research endeavors to develop novel, environmentally friendly cements raise questions regarding their ...
Matteo Stefanoni, Ueli M. Angst, Bernhard Elsener   +2 more
doaj   +1 more source

Development of sustainable material for hybrid wall system to improve indoor thermal performance [PDF]

, 2017
Thermal performance of building envelope has been of great importance in determining the indoor thermal environment mainly due to the impact of existing global warming issues.
Narendra raut, Ashwin
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Energetic Performance of Natural Building Materials: Numerical Simulation and Experimental Evaluation

Energies
The current goal of the European Commission, which aims to reduce CO2 by 90% compared to values estimated in 1980, and the ever-increasing sensitivity to environmental sustainability, fully involve the construction sector, which, according to the OECD ...
Costantino Carlo Mastino, Giovanna Concu, Andrea Frattolillo   +2 more
doaj   +1 more source

Degradation Mechanisms of Transparent Polyurethane Interlayer under UV Irradiation

Journal of Aeronautical Materials, 2017
According to the ageing problem of laminated transparency, the trasparent polyurethane film used as interlayer had been irradiated by fluorescent ultraviolet lamp for 0 h, 200 h, 300 h, and 500 h respectively.
OU Yingchun, MA Xiaona, ZHANG Yanfang, FU Jing, QIN Ruixiang, MA Juanrong   +5 more
doaj   +1 more source