Results 61 to 70 of about 105,339 (264)

Selection of the kinematic scheme and determination of the main characteristics of the generator-drive unit from the axis of the wheelset of a three-element freight bogie

open access: yesВестник Научно-исследовательского института железнодорожного транспорта, 2017
At present, large-capacity refrigerated containers (LCRC) are widely used for the transport of perishable goods. Transportation of such containers by rail is carried out by couplings of 10-12 fitting platforms and a car with diesel-electric power station.
V. G. Kargin   +4 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Building typology: analysis of the building stock and typologies definition [PDF]

open access: yes
Futureproofing historic buildings on a large scale is an ambitious target: carbon neutrality goals call for quick actions; instead, the energy retrofitting of historic buildings requires complex planning to optimize the energy savings with the preservation of cultural value.
Poma, Elena, Herrera-Avellanosa, Daniel
openaire   +2 more sources

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

open access: yesFEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan   +2 more
wiley   +1 more source

SIMULATION OF DYNAMIC INTERACTION BETWEEN THE BODY OF THE PASSENGER CAR AND TRUCKS

open access: yesNauka ta progres transportu, 2008
The results of mathematical simulation of spatial oscillations of passenger coaches for determination of forces of dynamical interaction of bodies and bogies, which are used in determination of dynamic run and strength characteristics, are presented in ...
V. I. Prykhodko, S. V. Myamlin
doaj  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

open access: yesFEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima   +8 more
wiley   +1 more source

Market transformations: gas conversion as a blueprint for net zero retrofit

open access: yesBuildings & Cities
All UK net zero scenarios call for zero gas use in homes by 2050. Delivering this along with any enabling measures is the largest heating market transformation since the gas conversion in the period 1965–77.
Aaron Gillich
doaj   +1 more source

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