Results 111 to 120 of about 317,136 (266)

Evaluating the Outcomes of the Capacity-Building Support From a Collaborative Network of Implementation Science Technical Assistance Hubs: Protocol for a Mixed Methods Evaluation. [PDF]

JMIR Res Protoc
Lee SJ, Mestel H, Audet CM, Balasubramanian B, Benbow N, Chandra S, Geremia C, Hernandez-Ramirez RU, Jones JL, Keatley O, Kemp C, Khosropour CM, Lanzi RG, Millett ME, Morshed AB, Pettit AC, Powers A, Rabin BA, Sales JM, Stadnick NA, Humphries D.   +20 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The landscape of academic global surgery in Canada: a national environmental scan. [PDF]

Can J Surg
El Sewify O, Patel P, Datta S, Fields E, Mastalerz-Sanchez K, Jemec B.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The development and utility of frameworks designed to evaluate research capacity building initiatives in healthcare settings: a methodological review. [PDF]

Health Res Policy Syst
King OA, Ottrey E, Conlin M, Yoong SL, Wong Shee A, West E, Alston L, Porter J, Huggins CE.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

New Technologies for Surveying Building Ruins

, 2009
Over the centuries, our rich architectural heritage has been exposed to many different phenomena: total neglect, continuous use, constant transformation and a partial loss of integrity. Destructive events and, sometimes, lack of use mean we have inherited some structures as ruins.
TUCCI, GRAZIA, BONORA, VALENTINA, N. Crocetto, NOBILE, ALESSIA   +3 more
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Promoting Planetary Health, One Bite at a Time: Examining the Efficacy and Feasibility of a Dietary Behaviour Change Intervention. [PDF]

Health Promot J Austr
Yip H, Wu J, Gleeson J, Tan W, Wong ZY, Holden S, Barbour L.   +6 more
europepmc   +1 more source