Results 121 to 130 of about 317,136 (266)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Evaluating the feasibility and effectiveness of a capacity-building model to nurture junior independent clinical research investigators in Uganda. [PDF]

PLoS One
Nanvuma A, Musaazi J, Twimukye A, Nakate V, Kiragga A, Laker-Oketta M, Sekaggya-Wiltshire C, Manabe YC, Castelnuovo B.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Scientific diasporas in global biodiversity governance: brain circulation, linkage, and knowledge brokerage in Colombia. [PDF]

Front Res Metr Anal
Prieto J, Matiz-Rubio N, González C, Posada-Pérez VM, Quintero Uribe LC, Fernández-Niño M, Charria-Girón E, Medina M, Colmenares-Quintero RF, Flórez-Cuadros M, Tibaduiza Y.   +10 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Modelling Cumulative Seismic Damage at the Urban Scale. [PDF]

Entropy (Basel)
Sava RM, Greco A, Pluchino A, Rapisarda A.   +3 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Laser-based survey of building objects and buildings

, 2019
Interessen for å bruke BygningsInformasjonsModeller (BIMer) i forvaltning, drift og vedlikehold av bygninger er økende. Ulike teknologier for innsamling av data for å etablere slike modeller er i rask utvikling. De vanligste teknologiene er basert på bilder, strukturert lys, laser eller en kombinasjon av disse.
openaire   +1 more source

Occupational heat stress in hospital settings: a combined assessment of staff perceptions and indoor climate to support heat action planning. [PDF]

BMC Public Health
Scheidl ST, Kaspar-Ott I, Hertig E.
europepmc   +1 more source