Results 81 to 90 of about 193,655 (266)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Q-optimised nanoelectromechanical diamond resonators

Microsystems & Nanoengineering
Nanomechanical resonators are increasingly becoming of interest across a range of applied and fundamental physics applications. Within many of these, the retention of bulk diamond’s high Young’s modulus, coupled with the compatibility with standard ...
Evan L. H. Thomas, Soumen Mandal, William G. S. Leigh, Oliver A. Williams   +3 more
doaj   +1 more source

Changing paradigms in bioequivalence trials submitted to the EMA for evaluation – A clinical and regulatory perspective

Saudi Pharmaceutical Journal, 2017
Background: The selection of a robust bioequivalence (BE) study designs for registering a generic product remains still a hard task. This task is still challenging despite the fact that generic products are much needed by health care providers in ...
Nathaniel Refalo, Daniel Chetcuti, Amy Tanti, Anthony Serracino-Inglott, John Joseph Borg   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Quasi square wave operation of modular multilevel converter based dual active bridge DC–DC converter with inductor energy recovery

IET Power Electronics
The modular multilevel DC–DC transformer (MMDCT) provides a reliable solution to overcome the challenges of conventional dual‐active‐bridge converters in terms of power semiconductors ratings and dv/dt stress on transformer coupling windings.
Peizhou Xia, Chuantong Hao, Paul Judge, Michael Merlin, Stephen Finney   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Research on Work Performance of Monolithic Precast Concrete Shear Walls with Post-Cast Epoxy Resin Concrete

Buildings
Precast concrete structures are popular in the building industry because of their high efficiency and environmental friendliness. In this paper, the U-type reinforcement ferrule connection technique was applied to study the seismic performance of precast
Peiqi Chen, Zihao Liu, Xiaojie Zhou, Shuo Xu, Junyi Wang   +4 more
doaj   +1 more source

Comparison between Modelled and Measured Magnetic Field Scans of Different Planar Coil Topologies for Stress Sensor Applications

Sensors, 2018
The investigation of planar coils of differing topologies, when combined with a magnetostrictive amorphous ribbon to form a stress-sensitive self-inductor, is an active research area for applications as stress or pressure sensors.
Robert Gibbs, Gregory Moreton, Turgut Meydan, Paul Williams   +3 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source