Results 101 to 110 of about 2,344,965 (309)

Energy efficiency of social housing existing buildings – a portuguese case study [PDF]

, 2011
The European energy performance building regulations, Directive 2002/91/EC - Energy Performance of Buildings Directive (EPBD) of the European Parliament and Council, require that new buildings present minimum standards of energy efficiency. Accordingly
Cardoso, José Claudino, Rodrigues, Maria Fernanda, Vicente, Romeu da Silva   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Advancing methane mitigation in ruminants through feed additive combinations: efficacy, interactions, and implementation challenges

Frontiers in Microbiology
Feed additives have emerged as promising strategies to lower enteric methane (CH₄) emissions, with some achieving reductions of up to 30%. However, their widespread adoption is limited by inconsistent effects on productivity, regulatory barriers, and ...
Eva Ramos-Morales, Juan Manuel Palma-Hidalgo, John Richard Newbold, Zaira Pardo, David R. Yañez-Ruiz, Charles James Newbold   +5 more
doaj   +1 more source

Integrated simulation for (sustainable) building design : state-of-the-art illustration [PDF]

, 2001
Many buildings are still constructed or remodelled without consideration of energy conserving strategies or other sustainability aspects. To provide substantial improvements in energy consumption and comfort levels, there is a need to treat buildings as ...
Clarke, J.A., Hensen, J. L. M.
core  

Building Trust

AJN, American Journal of Nursing, 2021
Nurses can help change the course of the COVID-19 pandemic.
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Green Municipal Building Ordinances [PDF]

, 2010
In 2006 the town of Babylon, NY adopted a local law that requires LEED certification for “new construction of commercial buildings, office buildings, industrial buildings, multiple residence, or senior citizen multiple residence over 4,000 square feet ...
Budniews, Donna
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source