Results 121 to 130 of about 2,344,965 (309)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Datasets of Faults in Variable Air Volume Terminal Units in a Multi-Zone Commercial Building
Scientific DataFaults in HVAC systems can decrease system efficiency and equipment lifespan, leading to 5%–30% of energy consumption being wasted in commercial buildings.
Sungkyun Jung, Yeobeom Yoon, Piljae Im
doaj +1 more source
Effect of Temperature on Physical and Mechanical Properties of Monolithic Polycarbonate
Structural Mechanics of Engineering Constructions and BuildingsThe study of the physical and mechanical properties of polycarbonate under various temperature conditions, taking into account its widespread use as a base material of monolithic polycarbonate systems in various climatic regions, will ensure a high ...
Kirill V. Avdeev +5 more
doaj +1 more source
Too Good to be True?: The Opportunity and Cost of the $1 Building [PDF]
, 2015 A study commissioned by The Kresge Foundation's Arts & Culture Program finds that arts organizations have experienced a wide range of outcomes when acquiring low-cost or free buildings, also known as "$1 buildings." In many cases, the actual costs of ...
Kate Burgin +2 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Tits buildings and K-stability
, 2018 A polarized variety is K-stable if, for any test configuration, the Donaldson-Futaki invariant is positive. In this paper, inspired by classical geometric invariant theory, we describe the space of test configurations as a limit of a direct system of ...
Codogni, Giulio
core +1 more source
"Build, build, build" - new permitted development rights [PDF]
, 2020 Reviews reforms to the Town and Country Planning (General Permitted Development) (England) Order 2015 Pt 20, to permit construction of up to two extra storeys on many purpose-built blocks of flats, without planning permission. Examines the restrictions on the permitted development right, the factors relevant to prior approval applications, the role of ...
openaire
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Study on the Bond Performance of Epoxy Resin Concrete with Steel Reinforcement
BuildingsEpoxy resin concrete, characterized by its superior mechanical properties, is frequently utilized for structural reinforcement and strengthening. However, its application in structural members remains limited.
Peiqi Chen +4 more
doaj +1 more source