Results 111 to 120 of about 2,344,965 (309)

Changing paradigms in bioequivalence trials submitted to the EMA for evaluation – A clinical and regulatory perspective

open access: yesSaudi Pharmaceutical Journal, 2017
Background: The selection of a robust bioequivalence (BE) study designs for registering a generic product remains still a hard task. This task is still challenging despite the fact that generic products are much needed by health care providers in ...
Nathaniel Refalo   +4 more
doaj   +1 more source

Dynamic Characteristics of Woodframe Buildings [PDF]

open access: yes, 2002
The dynamic properties of wood shearwall buildings were evaluated, such as modal frequencies, damping and mode shapes of the structures. Through analysis of recorded earthquake response and by forced vibration testing, a database of periods and damping ...
Beck, J. L., Camelo, V. S., Hall, J. F.
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Q-optimised nanoelectromechanical diamond resonators

open access: yesMicrosystems & Nanoengineering
Nanomechanical resonators are increasingly becoming of interest across a range of applied and fundamental physics applications. Within many of these, the retention of bulk diamond’s high Young’s modulus, coupled with the compatibility with standard ...
Evan L. H. Thomas   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Quasi square wave operation of modular multilevel converter based dual active bridge DC–DC converter with inductor energy recovery

open access: yesIET Power Electronics
The modular multilevel DC–DC transformer (MMDCT) provides a reliable solution to overcome the challenges of conventional dual‐active‐bridge converters in terms of power semiconductors ratings and dv/dt stress on transformer coupling windings.
Peizhou Xia   +4 more
doaj   +1 more source

Research on Work Performance of Monolithic Precast Concrete Shear Walls with Post-Cast Epoxy Resin Concrete

open access: yesBuildings
Precast concrete structures are popular in the building industry because of their high efficiency and environmental friendliness. In this paper, the U-type reinforcement ferrule connection technique was applied to study the seismic performance of precast
Peiqi Chen   +4 more
doaj   +1 more source

Comparison between Modelled and Measured Magnetic Field Scans of Different Planar Coil Topologies for Stress Sensor Applications

open access: yesSensors, 2018
The investigation of planar coils of differing topologies, when combined with a magnetostrictive amorphous ribbon to form a stress-sensitive self-inductor, is an active research area for applications as stress or pressure sensors.
Robert Gibbs   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Involvement of People in the Design of Community Building in Developing Countries [PDF]

open access: yes, 2013
Although public participation concept or technique to enhance and /or influence decision making is a fact of life in many governments nowadays and has been used by many industries to improve their products and increase end-users satisfaction, it is still
Alalem, Mohamed   +2 more
core  

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