Results 51 to 60 of about 1,571,080 (298)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Unpacking Demographics-Based Impediments to Professionalization in the South African Built Environment

Buildings
Despite South Africa’s unique demographics, shaped by a history of apartheid and ongoing inequality, its built environment has so far been unable to extricate itself from its inglorious past.
Molusiwa Ramabodu, Tholang David Nena
doaj   +1 more source

Empowering local governments to make a disaster resilient built environment within Sri Lankan Cities [PDF]

, 2013
Urban areas are growing very rapidly all over the world, particularly in developing countries. As a result of rapid urbanisation, the world’s population is increasingly concentrated in large cities leading to unplanned urban development with ...
Amaratunga, Dilanthi, Haigh, Richard, Malalgoda, Chamindi   +2 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Digital Twin Technology in Built Environment: A Review of Applications, Capabilities and Challenges

Smart Cities
Digital Twin (DT) technology is a pivotal innovation within the built environment industry, facilitating digital transformation through advanced data integration and analytics.
Yalda Mousavi, Zahra Gharineiat, Armin Agha Karimi, Kevin McDougall, Adriana Rossi, Sara Gonizzi Barsanti   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Using open-source data to explore distribution of built environment characteristics across Kerala, India

Indian Journal of Public Health, 2020
Background: Built environment characteristics in the neighborhood are of utmost priority for a healthy lifestyle in the fast-urbanizing countries. These characteristics are closely linked to the disease burden and challenges in low- and middle-income ...
Joanna Sara Valson, V Raman Kutty, Biju Soman, V T Jissa   +3 more
doaj   +1 more source

The Data Processing Pipeline for the Herschel-HIFI Instrument [PDF]

, 2019
The HIFI data processing pipeline was developed to systematically process diagnostic, calibration and astronomical observations taken with the HIFI science instrumentas part of the Herschel mission.
Edwards, K., Kester, D., Lorenzani, A., Melchior, M., Shipman, R. F.   +4 more
core   +2 more sources