Results 61 to 70 of about 1,571,080 (298)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

BIM as a Tool for Developing Smart Buildings in Smart Cities: Potentialities and Challenges

Architecture
Building Information Modeling (BIM) has established itself as a strategic and indispensable tool for designing and implementing smart buildings within the context of smart cities.
Carlos Eduardo Gomes de Souza, Christine Kowal Chinelli, Carlos Alberto Pereira Soares, Orlando Celso Longo   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Overcoming data utilization challenges for built environment flood resilience: Strategies and best practices

Journal of Flood Risk Management
Built environment flood resilience is a critical challenge facing communities worldwide. Amongst various efforts to resilience, the conception towards data utilization becomes popular with enormous technological advancements.
Pavithra Rathnasiri, Onaopepo Adeniyi, Niraj Thurairajah   +2 more
doaj   +1 more source

Climate change impact on the architecture and built environment dwellers’ well-being in Niger Delta Region: a systematic review

Frontiers in Climate
Climate change resulting from weather conditions has recently attracted global attention and concern; such variations have impacted architecture and the built environment, especially on the urban dweller’s well-being and other associated urban problems ...
Kingsley O. Dimuna, Kingsley O. Dimuna, Eghosa N. Ekhaese, Onyedikachukwu O. Ndimako   +3 more
doaj   +1 more source

“Feeling at home” for people with dementia in care environments.

Convergências - Revista de Investigação e Ensino das Artes, 2021
This review summarises the challenges of applying evidence that built environment factors contribute to people with dementia feeling at home in long-term care institutions.
Jing Chen, Silvia Maria Gramegna, Alessandro Biamonti   +2 more
doaj   +1 more source

Integration of virtual reality within the built environment curriculum [PDF]

, 2006
Virtual Reality (VR) technology is still perceived by many as being inaccessible and cost prohibitive with VR applications considered expensive to develop as well as challenging to operate.
Hamza, Neveen, Horne, Margaret
core  

NFV Based Gateways for Virtualized Wireless Sensors Networks: A Case Study

, 2015
Virtualization enables the sharing of a same wireless sensor network (WSN) by multiple applications. However, in heterogeneous environments, virtualized wireless sensor networks (VWSN) raises new challenges such as the need for on-the-fly, dynamic ...
Glitho, Roch, Morrow, Monique, Mouradian, Carla, Polakos, Paul, Saha, Tonmoy, Sahoo, Jagruti   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Virtual audits of the urban streetscape: comparing the inter-rater reliability of GigaPan® to Google Street View

International Journal of Health Geographics, 2020
Background Although previous research has highlighted the association between the built environment and individual health, methodological challenges in assessing the built environment remain.
Katherine N. Bromm, Ian-Marshall Lang, Erica E. Twardzik, Cathy L. Antonakos, Tamara Dubowitz, Natalie Colabianchi   +5 more
doaj   +1 more source