Results 121 to 130 of about 2,592,786 (294)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Symmetry-driven bulk-edge correspondence in electron magnetofluids at finite temperature
Physical Review ResearchWe present a theoretical framework connecting the pseudo-Chern number in momentum space to the spectral flow index in phase space for continuous media, with specific applications to topological Langmuir-cyclotron waves (TLCWs) in magnetized plasmas at ...
Xianhao Rao +3 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Physical Review XThe Středa formula establishes a fundamental physical connection between the topological invariants characterizing the bulk of topological matter and the presence of gapless edge modes.
Lucila Peralta Gavensky +2 more
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Towards more inclusive long-term bulk water resource management [PDF]
Fresh water resources provide a platform for complex and often emotional issues to develop, particularly in resource scarcity situations. Bulk water infrastructure contains elements of a public good and proved vulnerable to failures in market and ...
Kleynhans, Theo E., de Lange, Willem J.
core
Topological edge states at Floquet quantum criticality
Communications PhysicsTopologically protected edge states exactly at topological phase boundaries challenge the conventional belief that topological states must be associated with a bulk energy gap.
Longwen Zhou, Jiangbin Gong, Xue-Jia Yu
doaj +1 more source
CMOS bulk-driven mixers with passive baluns
, 2008 The design, simulation, and measurement of two bulk-driven down-conversion mixers with on-chip transformer baluns in 0.18 μm CMOS is presented. Applying either the RF signal or the local oscillator (LO) signal to the bulk connection of the transistors allows the amplification and switching stages of a conventional mixer to be combined into a single ...
openaire +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source