Results 71 to 80 of about 774,751 (285)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Increment thickness versus dentin bond strength of bulk fill flowables [PDF]

, 2013
Objectives: The aim was to investigate the influence of increment thickness on shear bond strength (SBS) to dentin of a conventional and two bulk fill flowable composites.
Lussi, Adrian, Flury, Simon, Peutzfeldt, Anne   +2 more
core  

Bulk-Fill Composites: A Review of the Current Literature.

The journal of adhesive dentistry, 2017
The aim of this article was to provide an overview of the literature on the currently available bulk-fill composites, and to describe the common trends as well as the wide variations. The findings may help the clinician to select the proper material with regard to its applicability in various clinical situations.
Van Ende, Annelies, De Munck, Jan, Lise, Diogo Pedrollo, Van Meerbeek, Bart, Ermis, Banu   +4 more
openaire   +2 more sources

Color stability of Bulk-Fill composite restorations

Journal of Clinical and Experimental Dentistry, 2020
The color stability of the composite resin is an important property that influences its clinical longevity, which remains an inherent challenge to the material. Thus, the purpose of this study was to evaluate the color stability of bulk-fill resins when exposed to dye.Cavities were prepared in 80 bovine incisors, which were randomly assigned into 4 ...
Silva, Marianna-Falcão, Dias, Marlon-Ferreira, Lins-Filho, Paulo-Cardoso, Silva, Claudio-Heliomar-Vicente, Guimarães, Renata-Pedrosa   +4 more
openaire   +5 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Depth of cure of resin composites: is the ISO 4049 method suitable for bulk fill materials?

, 2012
To evaluate if depth of cure D(ISO) determined by the ISO 4049 method is accurately reflected with bulk fill materials when compared to depth of cure D(new) determined by Vickers microhardness ...
Lussi, Adrian, Hüsler, Jürg, Flury, Simon, Hayoz, Stefanie, Peutzfeldt, Anne   +4 more
core   +1 more source

Color Stability of Bulk-Fill Flowable Resin Composites After Artificial Aging

Dentistry Journal
Background: This study aimed to evaluate the color stability of bulk-fill flowable resin composites with 2 difference shades at baseline and after artificial aging. Methods: Disk-shaped specimens (Ø10 × 4 mm) were fabricated from three bulk-fill flowable
Franciele Floriani, Carlos A. Jurado, Nikkita Madhu, Mark A. Lackey, Francisco X. Azpiazu-Flores, Guilherme Carpena Lopes   +5 more
doaj   +1 more source

A comparative study of bulk-fill composites: degree of conversion, post-gel shrinkage and cytotoxicity

Brazilian Oral Research, 2018
: Bulk-fill composites are claimed to be restorative materials used in deep preparations and effectively photoactivated in layers up to 4 mm. The aim of the present study was to evaluate the degree of conversion, post-gel volumetric shrinkage, and ...
Flávia Gonçalves, Luiza Mello de Paiva Campos, Ezequias Costa Rodrigues-Júnior, Fabrícia Viana Costa, Pamela Adeline Marques, Carlos Eduardo Francci, Roberto Ruggiero Braga, Letícia Cristina Cidreira Boaro   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source