Results 91 to 100 of about 1,320,249 (296)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

On the bulk block expansion for a monodromy defect

, 2022
9 pages. 1 figure Significant Appendix added deriving the block expansion as an Appell $F_3$ function.
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Elastic properties of Zr-based bulk metallic glasses studied by resonant ultrasound spectroscopy [PDF]

We report measurements of the elastic properties of Zr-based bulk metallic glasses, Zr52.5Cu17.9Ni14.6Al10Ti5, Zr50Cu30Ni10Al10, and Zr50Cu40Al10 between 5 K and 300 K.
Zhang, Zhiying, Yokoyama, Yoshihiko, Liaw, Peter K., Keppens, Veerle, Inoue, Akihisa   +4 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Probing the effects of SHI and doping induced defects in nanocrystalline spinel ferrites

, 2005
Different types of defects have been introduced in ferrite thin films and bulk (powder) systems by implementing different methods namely swift heavy ion irradiation, impurity doping.and mechanical milling. Swift heavy ions (190 MeV Au ions and 150 MeV Ni
Gupta, Ajay (author), Ganesan, V. (author), Kundu, S. (author), Ghosh, Sanjukta (author), Raghavendra Reddy, V. (author), Kumar, Nitender (author), Gupta, Mukul (author), Khan, Saif Ahmed (author)   +7 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Multifunctional ionic liquid boosts the efficiency of hole transport layer‐free carbon‐based perovskite solar cells beyond 20%

FlexMat
The planar triple‐layer hole transport layer (HTL)‐free carbon‐based perovskite solar cells have the advantages of low cost and high stability, but their low efficiency hinders the commercialization process.
Zhiyang Ju, Wenyan Zhao, Jionghua Wu, Hongshi Li, Yumin Liu, Wenying Jiang, Tiankai Zhang, Chuanjin Tian, Shaojian Fu, Chang‐an Wang, Zhipeng Xie   +10 more
doaj   +1 more source

Entanglement entropy in integrable field theories with line defects II. Non-topological defect

Journal of High Energy Physics, 2017
This is the second part of two papers where we study the effect of integrable line defects on bipartite entanglement entropy in integrable field theories. In this paper, we consider non-topological line defects in Ising field theory.
Yunfeng Jiang
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source