Results 41 to 50 of about 17,747 (199)

Absence of the Klotho Function Causes Cornea Degeneration with Specific Features Resembling Fuchs Endothelial Corneal Dystrophy and Bullous Keratopathy. [PDF]

open access: yesBiology (Basel)
The Klotho loss-of-function mutation is known to cause accelerated senescence in many organs, but its effects on the cornea have not been published. The present study aims to investigate the effects of the Klotho null mutation on cornea degeneration and ...
Wu CY   +5 more
europepmc   +2 more sources

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

open access: yesAdvanced Science, Volume 13, Issue 41, 22 July 2026.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao   +10 more
wiley   +1 more source

A. Bullous Keratopathy before DSAEK with a clear lens. B. Clear corneal endothelial lenticule with a clear lens 12 months after DSAEK.

open access: yes, 2013
A. Bullous Keratopathy before DSAEK with a clear lens. B. Clear corneal endothelial lenticule with a clear lens 12 months after DSAEK.
Rong-mei Peng (405853)   +4 more
core   +1 more source

Bullous keratopathy: etiopathogenesis and treatment [PDF]

open access: yes, 2008
Bullous keratopathy is characterized by corneal stromal edema with epithelial or subepithelial bullae due to cell loss and endothelial decompensation.
Gonçalves, Eliana Domingues [UNIFESP]   +9 more
core   +1 more source

Prevalence, Treatment, and Outcomes of Corneal Disease in Aboriginal and Torres Strait Islander Peoples in Australia: A Systematic Review

open access: yesClinical &Experimental Ophthalmology, Volume 54, Issue 5, Page 653-663, July 2026.
ABSTRACT Background To synthesise available evidence on the prevalence, treatment strategies, and outcomes of corneal disease affecting Aboriginal and Torres Strait Islander peoples in Australia, and to identify gaps in the existing literature. Methods A systematic review with narrative synthesis was conducted in accordance with PRISMA 2020 guidelines.
Angus van der Nagel   +3 more
wiley   +1 more source

The results descemet-stripping automated endothelial keratoplasty at bullous keratopathy [PDF]

open access: yes, 2014
Purpose: to evaluate outcomes of the descemet-stripping automated endothelial keratoplasty using eye drops Kombinil-Duo dur- ing postoperative period.Methods: 26 patients suffered from bullous keratopathy underwent descemet-stripping automated ...
S. V. Trufanov
core   +1 more source

Descemet Membrane Endothelial Keratoplasty with cornea press technique and implantation of a Carlevale scleral-fixated intraocular lens

open access: yesAmerican Journal of Ophthalmology Case Reports, 2023
Purpose: We describe a combined Descemet Membrane Endothelial Keratoplasty (DMEK) using the Cornea-press (C-Press) technique, with implantation of a new sutureless, scleral fixated intraocular lens (IOL) (Carlevale, Soleko), in a case of bullous ...
Wassim Ghazal   +4 more
doaj   +1 more source

Comparison of treatments for bullous keratopathy in rabbits

open access: yesExperimental and Therapeutic Medicine, 2013
The aim of the present study was to compare deep lamellar endothelial keratoplasty (DLEK) and penetrating keratoplasty (PK) treatments for bullous keratopathy (BK). In total, 36 healthy New Zealand white rabbits were randomly divided into 3 groups termed the experimental, DLEK and PK groups. The experimental control group received no treatment.
ZHAO, HAIXIA   +3 more
openaire   +3 more sources

Exploring the histopathological signature of repeat‐mediated Fuchs endothelial corneal dystrophy

open access: yesActa Ophthalmologica, Volume 104, Issue 3, Page 333-341, May 2026.
Abstract Purpose To determine the histological differences between Fuchs endothelial corneal dystrophy (FECD) cases with and without the most common genetic risk factor, expansion of a CTG repeat (CTG18.1) within the TCF4 gene. Methods Formalin‐fixed paraffin‐embedded corneal tissues were compared retrospectively, and CTG18.1 status was determined from
Anne‐Marie S. Kladny   +5 more
wiley   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

open access: yesAdvanced Science, Volume 13, Issue 19, 2 April 2026.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang   +9 more
wiley   +1 more source

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