Results 171 to 180 of about 315,766 (302)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
cordage bandolier with attached perfume bundle
Rope knotted at equal intervals ended with colored raffia tassels and a black colored perfume bundle84.0 cmCordage bandolier, with attached perfume bundle. This bandolier was secured in trade from Albert Robinson, an Omaha Indian dance of Macy, Nebraska,
Omaha
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Effect of a prevention bundle for internal jugular vein malposition of peripherally inserted central catheters in children: a single-center before-after study. [PDF]
Front PediatrTokuda Y +4 more
europepmc +1 more source
, 2016 This article examines the enormous variety evident in the ‘social life’ of Kenyan khat (miraa) and the role of this variety in the creation and manipulation of value. The article, after a discussion of the literature on value and its relevance to miraa, describes variables used in distinguishing the many different types of miraa, describes how ...
openaire +2 more sources
COPD exacerbation care bundle improves standard of care, length of stay, and readmission rates
, 2016 Raj Parikh,1 Trushil G Shah,2 Rajive Tandon2 1Department of Internal Medicine, 2Department of Pulmonary and Critical Care Medicine, Rush University Medical Center, Chicago, IL, USA Introduction: COPD is the third leading cause of death in the world ...
Shah TG, Parikh R, Tandon R,
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Left Bundle Branch Area Pacing as a Rescue Strategy After Failed Cardiac Resynchronization Therapy in a Patient With Persistent Left Superior Vena Cava, Absent Coronary Sinus Branches, After Bilateral Maze Procedure: A Case Report. [PDF]
Am J Case RepKohoutková L, Augustynek M, Šipula D.
europepmc +1 more source