Results 81 to 90 of about 794,234 (341)

Locally trivial quantum vector bundles and associated vector bundles [PDF]

open access: yesarXiv, 2000
We define locally trivial quantum vector bundles (QVB) and QVB associated to locally trivial quantum principal fibre bundles. There exists a differential structure on the associated vector bundle coming from the differential structure on the principal bundle, which allows to define connections on the associated vector bundle associated to connections ...
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Mechanism Model of Critical Heat Flux in Bundle Based on High-precision Subchannel Code

open access: yesYuanzineng kexue jishu, 2023
Critical heat flux (CHF) is a crucial safety limit for PWR core design. Accurately predicting CHF in the core rod bundle channel can enhance the economy and safety of the reactor. Currently, the prediction of rod bundle CHF in engineering is mainly based
GUO Junliang;JIANG Li;GAO Kui;KONG Huanjun;GUI Miao;SHAN Jianqiang
doaj  

Canonical Involution on Double Jet Bundles [PDF]

open access: yesarXiv, 2016
In this study, we generalize double tangent bundles to double jet bundles. We present a secondary vector bundle structure on a 1-jet of a vector bundle. We show that 1-jet of a vector bundle carries two vector bundle structures, namely primary and secondary structures.
arxiv  

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

James bundles [PDF]

open access: yesProceedings of the London Mathematical Society, 2004
We study cubical sets without degeneracies, which we call □‐sets. These sets arise naturally in a number of settings and they have a beautiful intrinsic geometry; in particular a □‐set C has an infinite family of associated □‐sets Ji(C), for i = 1, 2, …, which we call James complexes.
Fenn, Roger   +2 more
openaire   +2 more sources

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

Parabolic Bundles and Parabolic Higgs bundles [PDF]

open access: yesarXiv, 2017
This is a survey article about parabolic bundles and parabolic Higgs bundles.
arxiv  

Loop Groups, Kaluza-Klein Reduction and M-Theory

open access: yes, 2004
We show that the data of a principal G-bundle over a principal circle bundle is equivalent to that of a \hat{LG} = U(1) |x LG bundle over the base of the circle bundle.
A. Adams   +24 more
core   +1 more source

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