Results 161 to 170 of about 70,917 (350)

Atrioventricular Delay Optimization in His-Optimized Cardiac Resynchronization Therapy: A Case Report. [PDF]

open access: yesClin Case Rep
Nguyen Quang M   +4 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Atrioventricular Junction Ablation with High-Definition Recording of Atrioventricular Node Potential. [PDF]

open access: yesJ Cardiovasc Dev Dis
Matteucci A   +8 more
europepmc   +1 more source

Two preferential conducting pathways within the bundle of His of the dog heart.

open access: yesThe Japanese Journal of Physiology, 1975
J. Alanís, D. Benítez
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Left Bundle Branch Area Pacing as an alternative to His Bundle pacing for Cardiac Resynchronization Therapy: a case report. [PDF]

open access: gold, 2020
Jean Yves Wielandts   +8 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

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