Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
The Manifestation of Bundle Branch Block due to Lesions within the His Bundle [PDF]
, 1978 Onkar S. Narula
openalex +1 more source
Bundle branch reentry with His dissociation—The His bundle: Bystander or participant? [PDF]
HeartRhythm Case Reports, 2018 Maged F. Nageh +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Bundle of His electrograms in congenital corrected transposition of the great arteries. A study of two adult cases. [PDF]
, 1973 H S Friedman +4 more
openalex +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
His bundle recordings in bradycardia-dependent AV block induced by premature beats. [PDF]
, 1975 Agustín Castellanos +4 more
openalex +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Disappearing His deflection. Electrophysiological evidence for conduction defect within the His bundle. [PDF]
, 1978 G. Csapo, A. Weisswange
openalex +1 more source
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source