Results 51 to 60 of about 56,890 (217)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Early Deterioration of the Right Ventricular Pacing Threshold Predicts the Increase in His‐Bundle Pacing Threshold During the Chronic Phase: A Single‐Center Retrospective Study

Journal of Arrhythmia
Background His‐bundle pacing (HBP) facilitates physiological ventricular activation. However, concerns about long‐term threshold deterioration persist. The predictors of chronic threshold elevation are not yet well established.
Kenji Baba, Shogo Sakamoto, Moritoshi Irishio, Tomotaka Yoshiyama, Yusuke Hayashi, Toru Kataoka, Daiju Fukuda   +6 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Concealed WPW Syndrome with Longitudinal Dissociation in the His Bundle Exhibiting Five Different Electrocardiographic Waveforms During Tachycardia

Journal of Arrhythmia, 2005
We examined a patient with concealed WPW syndrome who exhibited five different electrocardiographic waveforms during tachycardia. With the intracardiac electrogram, all tachycardia were artrioventricular reciprocating tachycardia with retrograde ...
Isao Kato, MD, Toru Iwa, MD, Yasushi Suzuki, MD, Takayuki Ito, MD   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Primer implante de electrodo de estimulación selectiva del haz de His en Colombia: Reporte de dos casos First implantation of selective his bundle pacing in Colombia: Report of two cases

Revista Colombiana de Cardiología, 2010
Se conoce que la estimulación en el ápex del ventrículo derecho produce disincronía ventricular y muchas veces los pacientes desarrollan miocardiopatía dilatada, lo que ha llevado a realizar una estimulación más fisiológica.
Jorge E Velásquez, Mauricio Duque, Jorge E Marín V, Julián M Aristizábal, Luis E Medina, Edgardo González, Laura Duque, William Uribe   +7 more
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A NOVEL GENETIC MARKER FOR INHERITED DISORDER OF THE HEART CONDUCTION SYSTEM

Российский кардиологический журнал, 2015
Aim. To study relation of mononucleotide polymorphism G>A of the gene SCN10A and development of inherited pathology of the heart conduction system.Material and methods. Totally, 260 persons investigated with primary disorders of cardiac conduction (71
S. Yu. Nikulina, A. A. Chernova, S. S. Tretyakova   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Block of branching portion of bundle of His from catheter shaft during ablation of left ventricular outflow tract ventricular premature complexes. [PDF]

Proc (Bayl Univ Med Cent), 2021
Haq A, Yousif A, Khan H, Deville B, Dohadwala M.   +4 more
europepmc   +1 more source