Results 71 to 80 of about 167,623,224 (301)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The phenomenon of concealed conduction in a case of His bundle pacing (HBP)

Journal of International Medical Research, 2020
The phenomenon of concealed conduction in His bundle pacing (HBP) has rarely been reported. We report here a patient who had 2: 1 atrioventricular block and complete left bundle branch block was used because of HBP. The patient developed continuous right
Shuai Sun, Hong Zhang, Xing-Peng Liu
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

His bundle electrocardiography in manifest and concealed right bundle branch extrasystoles

, 1977
His bundle electrocardiography was helpful in the diagnosis of impulse formation in the right bundle branch. Ten patients with narrow QRS complexes had ectopic beats with an “incomplete” left bundle branch pattern and almost simultaneous activation of ...
Ghahramani, Ali, Moleiro, Federico, Castellanos, Agustin, Mallon, Stephen M, Sung, Ruey J, Myerburg, Robert J   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Battery longevity and His bundle lead performance in His bundle pacing

Heart Rhythm O2
High capture thresholds and lead dislodgment are often cited as impediments for general adoption of His bundle pacing.We report on our experience in managing patients who underwent His bundle pacing with higher energy requirement and incidence of lead dislodgment in a mean duration of 33 months.In 1188 patients, pacing was done at the site of His ...
Ayush Mohan, Jenna Lee, Whitney Adams, Brittany Phillips, Sharon Hakes, Rehan Mahmud   +5 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Supernormal conduction in the canine bundle of His and proximal bundle branches

, 1980
We used close bipolar intramural electrodes and catheter electrodes to study the characteristics of conduction in the bundle of His and proximal bundle branches during premature atrial beats in 17 open-chest anesthetized dogs.
J. F. Spear, E. N. Moore
core   +1 more source

His resynchronization versus biventricular pacing in patients with heart failure and left bundle branch block [PDF]

, 2018
Background His bundle pacing is a new method for delivering cardiac resynchronization therapy (CRT). Objectives The authors performed a head-to-head, high-precision, acute crossover comparison between His bundle pacing and conventional biventricular CRT,
Koa-Wing, michael, muthumala, amal, Cole, graham, Keene, Daniel, Sohaib, Syed, Qureshi, norman, Whinnett, zachary, Tanner, mark, ellenbogen, kenneth, Howard, James, Linton, nick, Peters, N, lefroy, david, wright, ian, Lim, phang, Arnold, Ahranyan, Francis, darrel, Kanagaratnam, prapa, Davies, D, Shun-Shin, Matthew   +19 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source