Results 241 to 250 of about 42,523 (291)

Early life stress and hormonal status influence orexin‐1 receptor expression in structures regulating cardiorespiratory responses to CO2

Experimental Physiology, EarlyView.
Abstract Excessive cardiorespiratory responses to CO2 are a hallmark of panic disorder (PD). Female sex and exposure to early life stress are risk factors for PD. Neonatal maternal separation (NMS; 3 h/day, postnatal days 3–12) augments the ventilatory response to CO2 by ∼35% relative to controls; this effect is most notable during pro‐oestrus but is ...
Stéphanie Fournier, Julie Plamondon, Denis Richard, Richard Kinkead   +3 more
wiley   +1 more source

Buprenorphine: An Analgesic with an Expanding Role in the Treatment of Opioid Addiction

, 2002
Susan Robinson
openalex   +1 more source

Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction

Experimental Physiology, EarlyView.
Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber, Kiana M. Schulze, Andrew G. Horn, Tyler E. McCoach, Zachary J. White, K. Sue Hageman, Stephanie E. Hall, Peter Sandner, Brad J. Behnke, Timothy I. Musch, David C. Poole   +10 more
wiley   +1 more source

GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus

The Journal of Physiology, EarlyView.
Abstract figure legend Here, we find that GluN2D‐containing NMDA receptors (NMDARs) are expressed by most vasoactive intestinal peptide neurons in the inferior colliculus (IC). These receptors are less susceptible to Mg2+ blockade compared to GluN2A/B‐containing NMDARs, allowing ions to flow at resting membrane potential.
Audrey C. Drotos, Rachel L. Zarb, Victoria Booth, Michael T. Roberts   +3 more
wiley   +1 more source

Control of action potential afterdepolarizations in the inferior olive by inactivating A‐type currents through KV4 channels

The Journal of Physiology, EarlyView.
Abstract figure legend KV4 channel availability regulates inferior olive action potential duration. The durations of action potentials in inferior olive neurons (blue) depend strongly on preceding membrane potential, with afterdepolarizations varying over the physiological range by almost two orders of magnitude (open circles). Voltage clamp recordings
Ziyad W. Sultan, Marion Najac, Indira M. Raman   +2 more
wiley   +1 more source

Buprenorphine improved treatment retention in patients with heroin dependence

, 2003
Paul J. Fudala
openalex   +1 more source

Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury

The Journal of Physiology, EarlyView.
Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular junctions (NMJ). A full thickness model of VML injury to the tibialis anterior muscle of adult Lewis rats was used, and treatments included Herceptin, a ...
Jacob R. Sorensen, Daniel B. Hoffman, Christiana J. Raymond‐Pope, Thomas J. Lillquist, Amanda M. Russell, Benjamin T. Corona, Sarah M. Greising   +6 more
wiley   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

National consensus statement on opioid agonist treatment in custodial settings

Medical Journal of Australia, Volume 222, Issue 5, Page 262-268, March 2025.
Abstract Introduction Opioid use and dependence are prevalent among incarcerated people, contributing to elevated rates of overdose and other harms in this population. Opioid agonist treatment (OAT) has been shown to be an effective intervention to mitigate these risks. However, challenges to health care implementation in the custodial sector result in
Jocelyn Chan, Jon Cook, Michael Curtis, Adrian J Dunlop, Ele Morrison, Suzanne Nielsen, Rebecca J Winter, Thileepan Naren   +7 more
wiley   +1 more source

Prescription opioid supply‐restricting policies and hospital use by people prescribed opioid medications, Victoria, 2018–22: a controlled interrupted time series analysis

Medical Journal of Australia, EarlyView.
Abstract Objectives To investigate the combined effect of two policies for reducing prescription opioid supply in Australia on hospital use by people prescribed opioids in primary care. Study design Retrospective data linkage study; controlled interrupted time series analysis of linked primary care electronic medication records and hospital admissions ...
Suzanne Nielsen, Louisa Picco, Bosco Rowland, Nadine E Andrew, Taya A Collyer, Samanta Lalic, Rachelle Buchbinder, Christopher Pearce, Simon Bell, Dan I Lubman, Ting Xia   +10 more
wiley   +1 more source