Results 241 to 250 of about 43,211 (293)
Clinical and Public Health Guidelines, Volume 2, Issue 4, October 2025.ABSTRACT Introduction Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is common. Inconsistent recommendations among clinical practice guidelines for management of chronic pain contribute to suboptimal patient management.
Andrea J. Darzi +48 more
wiley +1 more source
Review of experimental equine synovitis models for inducing lameness
Equine Veterinary Education, Volume 37, Issue 10, Page 547-560, October 2025.Summary Lameness in horses, particularly in relation to osteoarthritis (OA), is complex and variable, highlighting the importance of experimental models in advancing our understanding of pain and lameness. Synovitis plays a critical role in the development of OA, and reversible models of synovitis offer valuable insights into physiology and potential ...
A. Dockery, B. Beasley, V. J. Moorman
wiley +1 more source
Buprenorphine improved treatment retention in patients with heroin dependence
, 2003 Paul J. Fudala
openalex +1 more source
Cancer, Volume 131, Issue 18, 15 September 2025.Abstract Background Opioid exposure during cancer therapy may increase long‐term unsafe opioid prescribing. This study sought to determine the rates of coprescription of benzodiazepine and opioid medications and new persistent opioid use after surgical treatment of early‐stage cancer.
Marilyn M. Schapira +15 more
wiley +1 more source
Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.A poly(hydroxy‐oxazolidone) (PHOx) is synthesized from CO2‐based precursors, enabling the up‐cycling of this waste material. After synthesis, PHOx shows thermoplastic properties, and can therefore be processed by many temperature‐dependent techniques. PHOx is hemocompatible, anti‐adhesive, and biocompatible, which is demonstrated in vitro and in vivo ...
Sofia F. Melo +11 more
wiley +1 more source
Advanced Science, Volume 12, Issue 33, September 4, 2025.L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang +6 more
wiley +1 more source
Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition
Advanced Science, Volume 12, Issue 33, September 4, 2025.Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu +12 more
wiley +1 more source
Biomedical Chromatography, Volume 39, Issue 9, September 2025.ABSTRACT Therapeutic drug monitoring of protein kinase inhibitors is widely practiced worldwide. Based on the example of ripretinib dosage requested by a clinician, we detailed the process of method development, using a literature‐based approach while ensuring the sustainability of the method to be as environmentally friendly as possible.
Cedric Rakotovao +10 more
wiley +1 more source
Dexmedetomidine-methadone-ketamine versus dexmedetomidine-methadone-alfaxalone for cats undergoing ovariectomy [PDF]
Adami, C +4 more
core +1 more source
Journal of Comparative Neurology, Volume 533, Issue 9, September 2025.Retinal projections in the Anna's hummingbirds (Calypte anna) where studied using intraocular injections of a neural tracer and compared to those of a non‐hovering species, the Zebra finch (Taeniopygia castanotis). Retinal targets in both birds were similar and correspond closely to those reported in other birds from a variety of avian clades ...
Cristián Gutiérrez‐Ibáñez +4 more
wiley +1 more source