Results 221 to 230 of about 62,498 (301)

Morinda Officinalis Oligosaccharides Alleviate Post‐Stroke Depression‐Like Behaviors Alongside Increased Gut Microbial Diversity and Butyrate Levels and Reduced Hippocampal Pla2g4a Expression

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
The mechanism by which MOO alleviates PSD in mice involves remodeling the gut microbiota to increase butyrate, thereby repairing the intestinal barrier and the blood–brain barrier. MOO and butyrate downregulate the hippocampal neuroinflammatory target Pla2g4a, while hippocampal overexpression of Pla2g4a counteracts the antidepressant effects of ...
Hui Ma, Yue Chen, Xinzhou Deng, Xuan Fang, Wenhui Xiao, Qian Long, Lu Du, Fuze Du, Haonan Chen, Yan Wang, Bo Gao, Xin Qiao   +11 more
wiley   +1 more source

Near Total Resolution of Severe Refractory Chronic Cough With Low-Dose Sublingual Buprenorphine: Case Report. [PDF]

Case Rep Psychiatry
Streem DW, Benovic J, Anand A.
europepmc   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1389-1401, November 2026.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

Approved Medications for Substance Use Disorders: An Umbrella Review of Systematic Reviews and Completed Phase 3 Randomized Controlled Trials. [PDF]

CNS Drugs
Danovitch I, Truman K, Brown H, Miller M, Shah S, Totlani J, Kaidbay DN, Tessema KK, Minasyan Z, IsHak WW, Miles S, Pechnick RN.   +11 more
europepmc   +1 more source

Monitoring Injected Drug Use in Greece Through Syringe Residue Analysis: A Multicity Study Within the ESCAPE Network

Drug Testing and Analysis, Volume 18, Issue 11, Page 1407-1417, November 2026.
A total of 2121 used syringes were analyzed in Athens, Thessaloniki, and Patras between 2022 and 2024. Distinct drug‐use patterns were observed across the three cities. Benzodiazepines, pregabalin, methadone, and fentanyl were increasingly detected in 2024.
Christina Matiaki, Anastasios Trakakis, Athanasios Theocharis, Chara Parpala, Chara Kotsailidou, Alexandros Psarianos, Emmanouil Chatzichristofis, Eleni Zagelidu, Panagiota Roussou, Nikolaos Raikos, Orthodoxia Mastrogianni   +10 more
wiley   +1 more source

An Ascorbic‐Acid Containing Poly(Carbonate) Urethane With Antioxidant Bioactivity for Application in Heart Valve Scaffold Development

Journal of Biomedical Materials Research Part A, Volume 114, Issue 11, November 2026.
ABSTRACT Prosthetic heart valve development consists of several branching, innovative strategies to mediate the complex native environment that wears down valve durability. Anti‐calcification treatments are being applied to pericardial tissue, durable polymers are being developed that mitigate oxidative degradation and stress cracking, and heart valve ...
Drake D. Pedersen, Keishi Kohyama, Taro Fujii, Marianna Barbuto, Sangho Ye, Sujeong Park, Flaviana Falci, Jooyoun Park, Keun Seok Seo, William Long, Antonio D'Amore, Seungil Kim, William R. Wagner   +12 more
wiley   +1 more source

Proof‐of‐Concept of an Intravital Murine Model to Observe the Spatiotemporal Distribution of Immune Cells Constituting the Foreign Body Response and Biomaterial Associated Infections

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 11, November 2026.
Development of a murine intravital ‘FBR‐through‐a‐window’ model enables longitudinal imaging of the spatiotemporal distribution of macrophages, neutrophils, myofibroblasts, and collagen during the foreign body response (FBR) and biomaterial‐associated infections (BAI). ABSTRACT Biomaterials are used more and more for permanent implantation in humans to
Elles C. Boonstra, Paul C. Jutte, Henny C. van der Mei, Aishi S. Satapathy, Anouk H. G. Wolters, Theo G. van Kooten, Jelmer Sjollema   +6 more
wiley   +1 more source