Results 101 to 110 of about 2,513,024 (300)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Estimating the burden of rheumatoid arthritis in Africa:A systematic analysis [PDF]
, 2012 Rheumatoid arthritis (RA) has an estimated worldwide prevalence of 1%. It is one of the leading causes of chronic morbidity in the developed world, but little is known about the disease burden in Africa. RA is often seen as a minor health problem and has
Abdel-Nasser +32 more
core +3 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Tracking poison ingestion deaths for South Africa: The need for access to timely reliable data
South African Medical JournalThe President of South Africa addressed the nation on 15 November 2024 regarding the rise in food-borne illnesses and related child deaths. In the absence of a clear profile of injury deaths from official cause-of-death data, we used empirical ...
M Prinsloo +6 more
doaj +1 more source
The burden of Alzheimer's disease
The International Journal of Neuropsychopharmacology, 2000 Alzheimer's disease (AD) imposes a severe burden upon patients and their carers. In particular, family carers of AD patients face extreme hardship and distress that represents a major but often hidden burden on healthcare systems. Carers often experience clinically significant alterations in physical and mental health, particularly depression. A number
openaire +2 more sources
Global Burden of Disease and Economic Growth [PDF]
Relationships between health and economic prosperity or economic growth are difficult to assess. The direction of the causality is often questioned and the subject of a vigorous debate.
Alassane Drabo +2 more
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
BMC Health Services Research, 2017 Background Information-use is an integral component of a routine health information system and essential to influence policy-making, program actions and research.
Edward Nicol +3 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Caring for Caregivers: Addressing Caregiver Burden in Newtown, Connecticut [PDF]
, 2017 In 2015, thirty-four million Americans provided unpaid care to an adult 50 years or older. Due to an aging population and an increased number of individuals living with chronic disease, the niche that caregivers occupy in healthcare administration will ...
Wunrow, Zachary
core +1 more source