In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The effect of food taxes and subsidies on population health and health costs: a modelling study
The Lancet Public Health, 2020 Summary: Background: One possible policy response to the burden of diet-related disease is food taxes and subsidies, but the net health gains of these approaches are uncertain because of substitution effects between foods.
Tony Blakely, ProfPhD +7 more
doaj +1 more source
Herpes zoster: burden of disease and current prevention strategies in Spain [PDF]
, 2023 Ángel Gil de Miguel, Isabel Jimeno Sanz
openalex +1 more source
Health, Environment and the Burden of Disease: A Guidance Note [PDF]
, 2003 This guidance note examines the conditions which determine whether an environmental hazard is responsible for a substantial amount of disease and whether feasible measures are available to prevent it.
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Global Burden of Disease and Economic Growth [PDF]
Relationships between health and economic prosperity or economic growth are difficult to assess. The direction of the causality is often questioned and the subject of a vigorous debate.
Alassane Drabo +2 more
core
Селянське і шляхетне, селянське і міське: взаємозв’язок народної та елітарної культури в середземноморській баладі про шляхетну пастушку [PDF]
, 2011 The plot of the Mediterranean ballad in the Romance tradition, known under the title of Noble pastora (the Noble Shepherdess), is analysed in this paper, largely on the examples of Castillian and Dalmatian variants.
Aicher +11 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Tracking poison ingestion deaths for South Africa: The need for access to timely reliable data
South African Medical JournalThe President of South Africa addressed the nation on 15 November 2024 regarding the rise in food-borne illnesses and related child deaths. In the absence of a clear profile of injury deaths from official cause-of-death data, we used empirical ...
M Prinsloo +6 more
doaj +1 more source