Results 171 to 180 of about 1,347,564 (265)

Global Burden of Disease disability weights for the US National Electronic Injury Surveillance System - All Injury Program. [PDF]

Inj Prev
Moberg ME, Steinmetz JD, Ong KL, Lenox H, Miller TR, Peterson C.   +5 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Burden and temporal trends of female-specific cancers in China: A systematic analysis of the 2023 global burden of disease study. [PDF]

PLoS One
Chen S, Yang X, Jiang S, Lin Y, Huang L, Chen H, Zheng J, Xie Y, Kuang Z.   +8 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Modifiable Risk Factors for Atrial Fibrillation/Flutter in the Association of Southeast Asian Nations: Global Burden of Disease 2021. [PDF]

JACC Adv
Baig MMA, Umar M, Manzoor I, Noor R, Tariq B, Usman FM, Bano S, Parkash C, Biswas S, Nabi R, Asim O, Awais AR, Mansoor M, Baig F, Ul Haq MA, Moiz MA, Zahoor RMW, Chew NW, Sattar Y.   +18 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Quantifying the fatal and non-fatal burden of disease associated with child growth failure, 2000-2023: a systematic analysis from the Global Burden of Disease Study 2023. [PDF]

Lancet Child Adolesc Health
GBD 2023 Child Growth Failure Collaborators.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Lay descriptions of painful temporomandibular disorders-an international consensus proposal for Global Burden of Disease estimates. [PDF]

BMC Med
Lövgren A, Liv P, Allison JR, Baad-Hansen L, Beecroft EV, Bergman S, Bijelic T, Bucci R, Böthun A, Christidis N, Colonna A, Draghici R, Drangsholt M, Durham J, Ernberg M, Giannakopoulos NN, Gonçalves DAG, Groenke B, Jusakos M, Lobbezoo F, Lua ESP, Lunecke G, Malysa A, Manfredini D, Marpaung C, Michelotti A, Moana-Filho E, Moreno B, Nilsson E, Nixdorf DR, Nykänen L, Oyarzo JF, Peck CC, Penlington C, Restrepo C, Rongo R, Schierz O, Stanisic N, Visscher CM, Wieckiewicz M, Xiong X, Xu YY, Yanez C, Häggman-Henrikson B, Svensson P.   +44 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source