Results 61 to 70 of about 6,763 (263)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Origin and Attribution of the Items in Eastern European Champlevé Enamels Style (Late 2nd – 4th Centuries) Found South-Eastward of the Main Dnieper Area

Нижневолжский археологический вестник
This article examines the origin and attribution of ornaments in Eastern European style found to the south and east of the main Dnieper area of such artifacts. Previously unknown artifacts are introduced into scientific circulation.
Oleg A. Radyush
doaj   +1 more source

The ritually disturbed burials of Yakuts (XVII–XVIII сenturies)

Вестник археологии, антропологии и этнографии, 2016
Basing on the analysis of the archaeological data on medieval burials of Yakuts we raise the problems of interpretation of graves with traces of an ancient ritual penetration and violation of burial structures and of anatomical integrity of the skeletons
Bravina R.I., Dyakonov V.M., Kolbina E.Yu., Petrov D.M.   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Archaeological Evidence of Proto-Bulgarian Presence in the Territory of Southern Bulgaria

Поволжская археология, 2012
The findings from Southern Bulgaria, mainly dated back to the 8th century, which researchers associate with proto-Bulgarian presence in the territory south of Stara Planina, are discussed. These are primarily funerary complexes of the 1st half through to
Borisov Boris
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The Kashi Artefacts in the Burials of the Zmeisky Catacomb Cemetery

Поволжская археология, 2018
The paper aims to the chronology of burials within the chambers and in the undercats of the catacombs and pit interments of the Zmeisky catacomb burial ground in Republic of North Ossetia-Alania (excavations 2013–2014), based on the analysis of kashi ...
Leontyeva Anna S.
doaj   +1 more source

A Quantitative Study of the Linear Pottery Culture Cemetery “Aiterhofen-Ödmühle”

Open Archaeology, 2021
This article emphasises on the results of the master´s thesis “Burials in Bytes. A Quantitative Study of Linear Pottery Cemeteries in Austria, Bohemia, Moravia and Southern Germany” and further elaborates on interpretations of identified patterns at ...
Hahnekamp Yanik
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source