Results 151 to 160 of about 24,412 (262)

Efficacy and Safety of Anal High‐Grade Squamous Intraepithelial Lesion Treatment Modalities: A Systematic Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background There is compelling evidence that treating high‐grade squamous intraepithelial lesions (HSIL), the anal squamous cell cancer (ASCC) precursor, reduces the risk of developing ASCC. Using high‐resolution anoscopy (HRA), surgical excision, ablative and topical therapies are widely used to treat HSIL.
Matthew Joseph Marino, Sophie Jones, Nicholas Reid Caldwell, Catherine Cartwright, Benedict Blacket, Richard Clive Turner   +5 more
wiley   +1 more source

Patch-type granuloma annulare mimicking bruises in a 9-year-old girl: first pediatric case report and literature review. [PDF]

BMC Pediatr
Xu X, Ding W, Lin Y.
europepmc   +1 more source

Investigating the Dietary, Economic, and Social Practices of a Neolithic Funnel Beaker Community in Wanna, Germany, Through Raw Material and Organic Residue Analyses of Pottery

Archaeometry, EarlyView.
ABSTRACT This study details the analysis of an assemblage of Funnel Beaker pottery from Wanna in Northern Germany investigated using petrographic, geochemical, and organic residue analyses. The analyses revealed specialized production of pottery vessels for funerary contexts, but that domestic and funerary pottery were used intensively to process ...
I. L. Wiltshire, K. Struckmeyer, A. Behrens, M. Mennenga, M. Roffet‐Salque   +4 more
wiley   +1 more source

An Updated Systematic Review of Topical Corticosteroid Withdrawal (TCSW): Steroid Addiction or Adverse Drug Effect? [PDF]

Cureus
Choi H, Orbe M, Esam S, Parker J.
europepmc   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Burning Mouth Syndrome and the Oral Microbiome: Unveiling Potential Links. [PDF]

Biomed Hub
Khorshidi Asl Z, Jafari F, Rezazadeh F, Kamyabi H.   +3 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Exploratory biomarker findings from regorafenib plus toripalimab in patients with refractory metastatic colorectal cancer (REGOTORI study). [PDF]

Gastroenterol Rep (Oxf)
Yao YC, He MM, Wang M, Mo YX, Zhao Q, Jin Y, Hou T, Chen YX, Wang F.   +8 more
europepmc   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source