Results 211 to 220 of about 1,472,869 (283)

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Correlation of duration of β-1,3/1,6-glucan administration with the effectiveness of immune stimulation in juvenile vimba bream <i>(Vimba vimba)</i>. [PDF]

J Vet Res
Kazuń B, Kazuń K, Małaczewska J, Kaminski R, Sikorska J, Wolnicki J.   +5 more
europepmc   +1 more source

Co‐Design Insights for Mechanically Active Flexible Printed Circuit Boards Through the CurveQuad Origami Robot

Advanced Science, EarlyView.
This paper presents the process of integrating electronics directly into the body sheet of CurveQuad, a small origami robot that can self‐fold, crawl, and steer with a single actuator. The authors design a flexible printed circuit board for the body sheet: the key challenge is to navigate how embedding electronics affects the mechanical properties and ...
Xuelin Wu, Daniel Feshbach, Satviki Vasireddy, Louis Beardell, Bao To, Yuliy Baryshnikov, Cynthia Sung   +6 more
wiley   +1 more source

Injectable dual-affinity self-assembling peptide hydrogels for local controlled delivery of therapeutic antibodies. [PDF]

Asian J Pharm Sci
Cui W, Zhang L, Yang C, He B, Zhang H, Wang X, Zhang Z, Zhang Q, Dai W.   +8 more
europepmc   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

GenX exposure induces neurodevelopmental impairment and synaptic toxicity in hESC-derived cerebral organoids. [PDF]

Mater Today Bio
Hyun SA, Lee YJ, Ko MY, Min E, Park H, Kim Y, Hwang DY, Lee BS, Ka M.   +8 more
europepmc   +1 more source

A Water Compartment Cell Culture Lid Enables Stable Longitudinal Recording of Neuronal Networks In Vitro

Advanced Science, EarlyView.
A cell culture lid with an integrated water compartment eliminates evaporation from microelectrode arrays while preserving gas exchange. Freed from the osmotic drift and repeated medium exchanges that disturb conventional recordings, patterned human iPSC‐derived neuronal networks are recorded continuously for five weeks. Single‐spike resolution reveals
Benedikt Maurer, Fabio Fischer, Giulia Amos, Vaiva Vasiliauskaitė, János Vörös   +4 more
wiley   +1 more source

Long Terminal Repeat Retrotransposons in Chenopodium quinoa Provide Insights Into Subgenome Differentiation and Altitudinal Adaptation. [PDF]

Plant Cell Environ
Sheng K, Wang F, Dong R, Liang Y, Wang KL, Lyu Q, Lin Y, Zhang L, Ding P, Ding M.   +9 more
europepmc   +1 more source

Stage‐Adaptive Bilayer Hydrogel Coordinates Photodynamic Antibacterial Therapy with Engineered Extracellular Vesicle–Mediated Immunomodulation in Infected Diabetic Wounds

Advanced Science, EarlyView.
Early photodynamic infection control and subsequent immunoregulatory repair are spatially separated within a stage‐adaptive bilayer hydrogel. Chlorin e6 is incorporated into the wound‐contacting layer to provide light‐triggered bactericidal therapy, whereas the upper layer regulates excessive reactive oxygen species before releasing microRNA‐146a ...
Gaofei Zhang, Boheng Zhu, Shihao Deng, Pan Du, Jun Pu, Xin Wang, Shuqian Dou, Yifei Wang, Wenjun Liu   +8 more
wiley   +1 more source

Non‐Canonical Function of DDX21 in Fetal Hematopoiesis Antagonizes KDM5A‐Mediated Repression of Ribosomal and Hematopoietic Genes

Advanced Science, EarlyView.
This study demonstrates a mechanism by which RNA helicase DDX21 coordinates the transcription of hematopoietic and ribosomal genes by interacting with the H3K4me3 demethylase KDM5A. The DDX21‐KDM5A complex co‐occupies active genes in hematopoietic progenitors, thereby ensuring their rapid proliferation during fetal hematopoiesis.
Adrian On‐Wah Leung, Chang Li, Xianyin Huang, Zhuming Fan, Yuning Chen, Jiaxing Liu, Hong Man Lin, Xiaoming Cui, Fujia Zhang, Ruoxi Niu, Kam Tong Leung, Boxian Huang, Hoi‐Hung Cheung   +12 more
wiley   +1 more source