Results 41 to 50 of about 12,829 (249)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Business game as method of training of cadets of emercom

Вестник Мининского университета, 2020
Introduction. Training cadets in educational institutions Of the state fire service of the EMERCOM of Russia to eliminate fires is an urgent task, the quality of which can be implemented using game forms of training.Materials and Methods.
V. V. Bulgakov
doaj   +1 more source

Vacancy‐Driven Ni Exsolution in Prussian Blue Analogues Creates Cooperative Defect–Metal Sites for Alkaline Hydrogen Evolution

Advanced Science, EarlyView.
Multimetal Prussian blue analogues (PBAs) are converted by low‐temperature Ar annealing into a cavity/CN‐vacancy architecture that triggers in situ Ni exsolution, creating dense Ni‐PBA interfacial motifs. These motifs optimize water dissociation and H* adsorption in alkaline media, delivering markedly accelerated HER kinetics and long‐term stability ...
Shiqi Wang, Haixian Yan, Hugo L. S. Santos, Md Mofakkharulhashan, Wenyi Huo, Pedro H. C. Camargo   +5 more
wiley   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Exploring the applicability of effectuation theory in distressed venture environments

Acta Commercii
Orientation: Once appointed, business rescue practitioners and turnaround professionals are faced with critical decision making of whether a distressed venture contains an opportunity as judged by reasonable prospect.
Thabang Madigoe, Marius Pretorius
doaj   +1 more source

What Really Drives Agri‐Environment‐Climate Measures' Adoption? Mandatory Requirements, Behavioral Traits, and Structural Factors in the CAP Green Architecture

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT To increase farmer adoption of green practices, the EU Common Agricultural Policy includes both mandatory (conditionality) and voluntary instruments (eco‐schemes–ECS– and more demanding, multi‐annual agri‐environment‐climate measures –AECM–). Building on the experiment of Barreiro‐Hurle et al.
L. Sanchez‐Mata, M. Rodríguez‐Entrena, M. Espinosa‐Goded, F. J. Dessart, J. Barreiro‐Hurlé   +4 more
wiley   +1 more source

Building on purposive interpretation outcomes to discern occupational practices from interview-to-the-double results

Journal of Management and Business Education
Studies leading to revised teaching and learning in business have relied on survey questionnaires without recognising multi-party data collection and evaluation procedures. The study demonstrates how the interview-to-the-double (ITTD) approach builds on
Onesmus Ayaya
doaj   +1 more source

Temporary Programs, Lasting Questions: Ad Hoc Assistance in the U.S. Farm Safety Net

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Large ad hoc assistance programs have returned to U.S. farm policy since 2017, operating alongside a more developed safety net built around federally subsidized crop insurance, Title I commodity programs, and standing disaster assistance. This paper reviews the renewed use of ad hoc assistance, documents its recent scale using USDA data, and ...
Alejandro Plastina, Oranuch Wongpiyabovorn   +1 more
wiley   +1 more source

Stakeholder expectations of the Business Rescue Plan from a South African perspective

The Southern African Journal of Entrepreneurship and Small Business Management, 2015
Background: A business rescue plan has to comply with a new and vague set of obligations regulated by South African legislation. Expectations of the plan are largely unknown, yet crucial in determining compliance.
Wesley Rosslyn-Smith, Marius Pretorius
doaj   +1 more source

Do Universal Free School Meals Improve the Dietary Quality of Food‐At‐Home Purchases?

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Since 2014, the number of schools offering universal free meals to all enrolled children without requiring annual meal applications has increased meaningfully. Using USDA's Purchase to Plate Crosswalk, a difference‐in‐differences framework, and a nationwide consumer panel, the effect of universal‐free‐meal exposure on the diet quality of food ...
Xueying Ma, Andres Cuadros‐Meñaca, Michael R. Thomsen   +2 more
wiley   +1 more source