Results 71 to 80 of about 3,215 (244)
Clinical Pharmacology &Therapeutics, EarlyView.Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó +7 more
wiley +1 more source
Associations Between Microbial Depletion and Autonomic Dysregulation in Binge‐Eating Disorder
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge‐eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio‐behavioral phenotype.
Shuang Liang +4 more
wiley +1 more source
EcoEnergy, EarlyView.A bifunctional molecular bridge using 4‐guanidinobutanoic acid (GCC) is constructed to comprehensively tailor the buried interface of PSCs. By passivating oxygen vacancies, optimizing energy‐level matching, and regulating perovskite crystallization, this strategy simultaneously boosts the power conversion efficiency to 25.37% (20.01% for 13.4 cm2) and ...
Ying Liang +12 more
wiley +1 more source
Carbon Anodes for Low‐Temperature Nonaqueous Alkali Metal‐Ion Batteries
EcoEnergy, EarlyView.This review summarizes recent progress in carbon anodes for low‐temperature nonaqueous alkali‐metal ion batteries. Fundamental thermodynamic and kinetic limitations are examined, alongside a systematic discussion of graphite, hard carbon, and emerging carbon architectures.
Zhichun Miao +11 more
wiley +1 more source
Charting Water‐in‐Natural‐Salt (WiNS) Electrolytes. Part I: Effect of Anion's Alkyl Tail Length
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.At 20 m, potassium carboxylates from formate to butyrate reveal anion tail‐controlled nanostructure. SAXS shows a pre‐peak shifting to lower q with chain length. Molecular dynamics reproduces S(q) and attributes it to concentration fluctuations forming bicontinuous segregation.
Alessandra Del Giudice +7 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source
ELECTROPHORESIS, EarlyView.A green CZE–UV alternative method for quantifying SCFAs in human stool with cost‐effective and automatization, informative data about patients through reduced sample preparation and minimal consumable. CE is simple and robust equipment for routine clinical laboratory workflows, supporting physicians with information that enhances the accuracy of ...
Olívia B. O. Moreira +6 more
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Objective The olive oil–based Mediterranean ketogenic diet (MedKD) may support patients with drug‐resistant epilepsy (DRE) or neurometabolic disorders by integrating ketogenic therapy with the cardiometabolic and neuroprotective advantages of the Mediterranean diet.
Sofia Zouganeli +8 more
wiley +1 more source
β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels
Epilepsia, EarlyView.β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi +8 more
wiley +1 more source