Results 1 to 10 of about 104,308 (265)

Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease

Cells, 2021
The microbial metabolite butyrate serves as a link between the intestinal microbiome and epithelium. The monocarboxylate transporters MCT1 and SMCT1 are the predominant means of butyrate transport from the intestinal lumen to epithelial cytoplasm, where ...
Robert Cowles, Pooja S Salvi
exaly   +3 more sources

Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

Frontiers in Microbiology, 2023
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological importance than the other major SCFAs (acetate and propionate).
Jae-Ho Shin, , Eun Soo Kim
exaly   +3 more sources

Butyrate blocks cell cycle progression in colorectal cancer organoids partially through HDAC2 inhibition [PDF]

Frontiers in Immunology
IntroductionButyric acid is a major gut microbiota metabolite that exhibits many biological functions, including the suppression of colorectal cancer (CRC) growth.
Banghui Liu, Yujun Huang, Xi Wang, Xiangjun Liu, Yikun Luo, Nan Wang, Hefei Tian, Hefei Tian, Lingxiao Huang, Zhenni Xu, Jinyi Lang, Xudan Lei, Dengqun Liu   +12 more
doaj   +2 more sources

The effects of β-caryophyllene on butyrate utilization and metabolism in Caco-2 cells [PDF]

Scientific Reports
Β-caryophyllene (BCP) is a plant compound that may exert bioactive effects on intestinal epithelial cell (IEC) function, including metabolism of butyrate, which is important for regulating cellular functions. The goal of this study was to investigate the
H. Scroggins, C. Kent-Dennis, J. May, D. L. Harmon, J. L. Klotz   +4 more
doaj   +2 more sources

Butyrate Properties in Immune-Related Diseases: Friend or Foe?

Fermentation, 2023
Butyrate is a short-chain fatty acid (SCFA) created within the intestinal lumen by bacterial fermentation of largely undigested dietary carbohydrates.
Muhammad Anshory, Raden Mohamad Rendy Ariezal Effendi, Handono Kalim, Reiva Farah Dwiyana, Oki Suwarsa, Tamar E. C. Nijsten, Jan L. Nouwen, Hok Bing Thio   +7 more
doaj   +1 more source

Polyvinyl Butyrate Nanoparticles as Butyrate Donors for Colitis Treatment

ACS Applied Bio Materials, 2021
Butyrate has been attracting attention for the suppression of inflammatory bowel disease (IBD). However, clinical trials of butyrate for IBD treatment have resulted in controversial outcomes, likely owing to the adverse effect of butyrate on the intestinal epithelium that was observed at high butyrate concentrations.
Yunmei Mu, Yusuke Kinashi, Jinting Li, Takuma Yoshikawa, Akihiro Kishimura, Mitsuru Tanaka, Toshiro Matsui, Takeshi Mori, Koji Hase, Yoshiki Katayama   +9 more
openaire   +3 more sources

Encapsulation of butyrate using low-alkali konjac gel induced by ethanol for colonic delivery

Food Hydrocolloids for Health, 2021
Butyrate administrated in proper concentration is beneficial to the human colon environment. However, the delivery of butyrate to the colon is quite difficult as butyrate could be easily absorbed in the upper gastrointestinal tract.
Yousong Ma, Sijia Peng, Ning Tang, Yongqiang Cheng   +3 more
doaj   +1 more source

Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression

Redox Biology, 2023
Ferroptosis has emerged to be a promising approach in cancer therapies; however, colorectal cancer (CRC) is relatively insensitive to ferroptosis. Exactly how the gut microenvironment impacts the ferroptotic sensitivity of CRC remains unknown. Herein, by
Ying He, Yuhang Ling, Zhiyong Zhang, Randall Tyler Mertens, Qian Cao, Xutao Xu, Ke Guo, Qian Shi, Xilin Zhang, Lixia Huo, Kan Wang, Huihui Guo, Weiyun Shen, Manlu Shen, Wenming Feng, Peng Xiao   +15 more
doaj   +1 more source

Crosstalk between butyrate oxidation in colonocyte and butyrate-producing bacteria

iScience, 2023
The composition of gut microbiota, including butyrate-producing bacteria (BPB), is influenced by diet and physiological conditions. As such, given the importance of butyrate as an energetic substrate in colonocytes, it is unclear whether utilization of this substrate by the host would enhance BPB levels, thus defining a host-microbiome mutualistic ...
Bohye Park, Ji Yeon Kim, Olivia F. Riffey, Triston J. Walsh, Jeremiah Johnson, Dallas R. Donohoe   +5 more
openaire   +2 more sources

Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice

Gut Microbes, 2021
Emerging research evidence has established the critical role of the gut-liver axis in the development of alcohol-associated liver disease (ALD). The present study employed 16S rRNA gene and whole genome shotgun (WGS) metagenomic analysis in combination ...
Richa Singhal, Hridgandh Donde, Smita Ghare, Kendall Stocke, Jingwein Zhang, Manicka Vadhanam, Sreelatha Reddy, Leila Gobejishvili, Paula Chilton, Swati Joshi-Barve, Wenke Feng, Craig McClain, Kristi Hoffman, Joseph Petrosino, Marius Vital, Shirish Barve   +15 more
doaj   +1 more source